Modified hemoglobin in hypoglycemia caused by hyperinsulinism

Abstract

Hemoglobin (Hb) was found to be modified in patients with prolonged hypoglycemia caused by hyperinsulinism. This modification was of a nonpolar nature, did not affect the overall charge of the Hb and caused its aggregation in aqueous solution. After normal concentrations of glucose and insulin were reestablished, this modification slowly disappeared. Hemoglobin from normal erythrocytes incubated in vitro with high concentrations of insulin showed similar behavior. © 1991.