Study of the mechanism of prostacyclin (PgI2) action of myocardial contractility

Abstract

The experiments done on the isolated right ventricle of rat hear suspended in the bath for isolated organs with oxygenated Tyrode's solution showed that PgI2 (2,3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2,3 x 10-2 mmol - beta adrenoreceptor blocker) or verapamil (4,3 x l0-3 mmol - slow calcium channel blocker).