Melanoma tumor inhibition by tetrachlorido(O,O′-dibutyl- ethylenediamine-N,N′-di-3-propionate)platinum(iv) complex: In vitro and in vivo investigations

Abstract

Tetrachlorido(O,O′-dibutyl-ethylenediamine-N,N′-di-3- propionate)platinum(iv) complex, [PtCl4(n-Bu2eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu2eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu2eddp)] concealed the expansion of tumors induced in syngeneic C57Bl/6 mice without visible signs of nephrotoxicity. © The Royal Society of Chemistry 2012.