Browsing by Author "Rosic, B. (6701690384)"

Determination of serum levels of alpha1 antitrypsin was carried out on 20 women with normal pregnancy and on 60 women with complicated pregnancy. The analysis was performed on the Beckman Immunochemistry Analyzer. In addition to control group there were three groups of patients with complicated pregnancy: group I consisted of pregnant women with diabetes mellitus, group II was composed of patients with high blood pressure, and group III of pregnant women with threatened abortion. In control group the authors did not detect any significant change in the serum level of alpha1 antitrypsin during all pregnancies. In patients with diabetes mellitus alpha1 antitrypsin levels were significantly decreased in the first three months of pregnancy. In pregnant women with threatened abortion alpha1 antitrypsin concentrations were significantly reduced in both first and second three months of pregnancy. There were no changes in serum levels of alpha1 antitrypsin in pregnant women with high blood pressure.

Complements C3 and C4, IgG, IgM, IgA and properdin factor B (PFB) were determined in maternal blood sera, sera from the umbilical cord and amniotic fluid in the group consisting of 30 healthy pregnant women and 30 patients with EPH gestoses. PFB and IgG were measured in urine, as well. Significant decrease of C3 complement in maternal sera and PFB in urine was found in the group with EPH gestoses, while a slight C4 complement enhancement was recorded in both maternal sera and the blood sera from the umbilical cord. PFB was conspicuously increased in maternal blood sera. IgG level was higher in the blood sera from the umbilical cord in comparison with that found in maternal sera in both groups examined. IgG, IgM and IgA levels were decreased in the group of patients with EPH gestoses in all fluids examined, while IgA level was significantly increased in the sera prepared from the blood from the umbilical cord.