Determination of alpha1 antitrypsin in pregnancy

Abstract

Determination of serum levels of alpha1 antitrypsin was carried out on 20 women with normal pregnancy and on 60 women with complicated pregnancy. The analysis was performed on the Beckman Immunochemistry Analyzer. In addition to control group there were three groups of patients with complicated pregnancy: group I consisted of pregnant women with diabetes mellitus, group II was composed of patients with high blood pressure, and group III of pregnant women with threatened abortion. In control group the authors did not detect any significant change in the serum level of alpha1 antitrypsin during all pregnancies. In patients with diabetes mellitus alpha1 antitrypsin levels were significantly decreased in the first three months of pregnancy. In pregnant women with threatened abortion alpha1 antitrypsin concentrations were significantly reduced in both first and second three months of pregnancy. There were no changes in serum levels of alpha1 antitrypsin in pregnant women with high blood pressure.