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Depression and parkinson's disease: possible role of serotonergic mechanisms

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dc.contributor.authorKostić, V.S. (35239923400)
dc.contributor.authorDjuričić, B.M. (7004603010)
dc.contributor.authorČovičković-Šternić, N. (6603691178)
dc.contributor.authorBumbaširević, L. (6506995589)
dc.contributor.authorNikolić, M. (7103334614)
dc.contributor.authorMršulja, B.B. (7006470637)
dc.date.accessioned2025-07-02T13:01:20Z
dc.date.available2025-07-02T13:01:20Z
dc.date.issued1987
dc.description.abstractDepression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression. © 1987 Springer-Verlag.
dc.identifier.urihttps://doi.org/10.1007/BF00314109
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0023282381&doi=10.1007%2fBF00314109&partnerID=40&md5=b620bae0a7931f96f0653ce63c4976a1
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14749
dc.subject5-Hydroxyindoleacetic acid
dc.subjectDepression
dc.subjectHuman cerebrospinal fluid
dc.subjectParkinson's disease
dc.titleDepression and parkinson's disease: possible role of serotonergic mechanisms
dspace.entity.typePublication

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