Ovarian response predictive model in different controlled ovarian stimulation protocols for IVF/ICSI treatment

Abstract

Purpose of investigation: Assesment of biomarkers of the ovarian reserve for ovarian response prediction using different controlled ovarian stimulation (COS) treatments. Materials and Methods: A retrospective cohort study included 363 patients who underwent assisted reproduction at the Clinic of Gynecology and Obstetrics, Belgrade, Serbia. Antral follicle count (AFC), serum AMH, inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone were measured on the second cycle day prior to stimulation commencement. Three types of ovulation stimulation protocols were used. The number and quality of obtained oocytes were used for evaluation of the ovarian response. Results: Patients' age, number of antral follicles, AMH level, and FSH/LH ratio were confirmed as predictors of the number of obtained oocytes. The AFC was the main parameter that influenced the number of obtained oocytes regardless of selected stimulation protocol. Conclusion: The individualization of stimulation protocols may be further improved by using both AFC- and AMH-tailored approach.