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T1/ST2 - An IL-1 receptor-like modulator of immune responses

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dc.contributor.authorTrajkovic, Vladimir (7004516866)
dc.contributor.authorSweet, Matthew J. (35373091000)
dc.contributor.authorXu, Damo (7404073685)
dc.date.accessioned2025-06-13T00:29:03Z
dc.date.available2025-06-13T00:29:03Z
dc.date.issued2004
dc.description.abstractTh2-associated factors such as IL-4 are involved in both the development of Th2 responses (via modulating Th2 cell differentiation) and in the effector phase of Th2 responses (via modulating macrophage activation). The IL-1 receptor-like protein ST2 (T1, Fit-1, or DER4) is expressed as a membrane-bound (ST2L) or secreted form (sST2), and has been clearly implicated as a regulator of both the development and effector phases of Th2-type responses. Here we analyze the mechanisms and therapeutic implications of the unique ability of ST2 to promote development and function of type 2 helper T cells through a positive feedback loop, as well as to act as a negative feedback modulator of macrophage pro-inflammatory function. © 2004 Elsevier Ltd. All rights reserved.
dc.identifier.urihttps://doi.org/10.1016/j.cytogfr.2004.02.004
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-1942535018&doi=10.1016%2fj.cytogfr.2004.02.004&partnerID=40&md5=3d9d8d5f592d5f8b9dafcd117672b127
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/11082
dc.subjectCytokines
dc.subjectIL-1
dc.subjectImmune response
dc.subjectT1/ST2
dc.subjectTh2
dc.subjectTLR
dc.titleT1/ST2 - An IL-1 receptor-like modulator of immune responses
dspace.entity.typePublication

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