Publication:
Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment?

Simple item page
dc.contributor.authorDrulovic, Jelena (55886929900)
dc.contributor.authorSavic, Emina (24822544200)
dc.contributor.authorPekmezovic, Tatjana (7003989932)
dc.contributor.authorMesaros, Sarlota (7004307592)
dc.contributor.authorStojsavljevic, Nebojsa (6603086728)
dc.contributor.authorDujmovic-Basuroski, Irena (6701590899)
dc.contributor.authorKostic, Jelena (57159483500)
dc.contributor.authorVasic, Vladimir (32467486300)
dc.contributor.authorStojkovic, Marija Mostarica (6701741422)
dc.contributor.authorPopadic, Dusan (6602255798)
dc.date.accessioned2025-07-02T12:46:41Z
dc.date.available2025-07-02T12:46:41Z
dc.date.issued2009
dc.description.abstractWe studied the effect of one-year interferon (IFN)-beta treatment on the in vivo mRNA expression of IFN-γ, interleukin (IL)-17, T-bet and RoR-γt, on peripheral blood mononuclear cells (PBMC) from 36 multiple sclerosis (MS) patients. In the total MS group, IFN-beta induced decrease in mRNA levels of IFN-γ and T-bet (p < 0.0001), while the levels of IL-17 and RoR-γt remained similar. In both responders and non-responders, IFN-beta induced significant decrease of IFN-γ (p < 0.0001 and p = 0.011, respectively), while decrease in T-bet was detected only in responders (p < 0.0001). Higher pre-treatment T-bet allowed prediction of the clinical response in the first year (β = 0.601, p = 0.036). Our preliminary findings suggest that T-bet expression might be a potential prognostic marker of treatment response to IFN-beta in MS. © 2009 Elsevier B.V. All rights reserved.
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2009.07.010
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70349853050&doi=10.1016%2fj.jneuroim.2009.07.010&partnerID=40&md5=203587be535f3f818d8196b4486622a0
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14213
dc.subjectIL-17
dc.subjectInterferon-beta
dc.subjectMultiple sclerosis
dc.subjectRoR-γt
dc.subjectT-bet
dc.subjectType 1 immunity
dc.titleExpression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment?
dspace.entity.typePublication

Files

Collections

Publikacije / Publications