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Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides

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dc.contributor.authorAljančić, Ivana S. (6602458297)
dc.contributor.authorPešić, Milica (36768679400)
dc.contributor.authorMilosavljević, Slobodan M. (7006371741)
dc.contributor.authorTodorović, Nina M. (6701783678)
dc.contributor.authorJadranin, Milka (15725185100)
dc.contributor.authorMilosavljević, Goran (53865455700)
dc.contributor.authorPovrenović, Dragan (6506406092)
dc.contributor.authorBanković, Jasna (24278374400)
dc.contributor.authorTanić, Nikola (7801574805)
dc.contributor.authorMarković, Ivanka D. (7004033826)
dc.contributor.authorRuždijić, Sabera (7003935669)
dc.contributor.authorVajs, Vlatka E. (35508693900)
dc.contributor.authorTešević, Vele V. (6602440793)
dc.date.accessioned2025-06-12T22:38:16Z
dc.date.available2025-06-12T22:38:16Z
dc.date.issued2011
dc.description.abstractFrom the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport. © 2011 The American Chemical Society and American Society of Pharmacognosy.
dc.identifier.urihttps://doi.org/10.1021/np200241c
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79960728011&doi=10.1021%2fnp200241c&partnerID=40&md5=0e66e9f06d2a47ba4233a3830c0ec72e
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/10027
dc.titleIsolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides
dspace.entity.typePublication

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