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Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women

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dc.contributor.authorQin, Yingying (55675073300)
dc.contributor.authorVujovic, Svetlana (57225380338)
dc.contributor.authorLi, Guangyu (55713601300)
dc.contributor.authorLi, Jin (55988914800)
dc.contributor.authorDalgleish, Raymond (7005949115)
dc.contributor.authorSimpson, Joe Leigh (7404325410)
dc.contributor.authorIvanisevic, Maja (12804221800)
dc.contributor.authorIvovic, Miomira (6507747450)
dc.contributor.authorTancic, Milina (25121743400)
dc.contributor.authorAl-Azzawi, Farook (35467712600)
dc.contributor.authorChen, Zi-Jiang (35227123300)
dc.date.accessioned2025-06-12T20:47:52Z
dc.date.available2025-06-12T20:47:52Z
dc.date.issued2014
dc.description.abstractObjective To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian). Design Case-control genetic association study in 197 Serbian POF cases and 552 matched controls. Results None of the SNPs found associated with POF in Chinese cohort were found to be associated in the Serbian sample. Conclusions In contrast to Han Chinese, no association was found between POF in Serbian women and any of the four tested loci: 8q22.3, HK3, ESR1 and BRSK1. This indicates that ethnically distinct populations may show differences in gene-regulating pathways and genes causing POF. © 2013 Elsevier Ireland Ltd.
dc.identifier.urihttps://doi.org/10.1016/j.maturitas.2013.09.006
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891682203&doi=10.1016%2fj.maturitas.2013.09.006&partnerID=40&md5=0ec1a056a0cc14414b4ff7a1d389b570
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/8926
dc.subject8q22.3
dc.subjectBRSK1
dc.subjectESR1
dc.subjectHK3
dc.subjectPremature ovarian failure (POF)
dc.titleEthnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women
dspace.entity.typePublication

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