Publication:
The kinetics of hypoxanthine efflux from the rat brain

Simple item page
dc.contributor.authorRedzic, Zoran B. (6602453895)
dc.contributor.authorIsakovic, Aleksandra (57202555421)
dc.contributor.authorSegal, Malcolm B. (7201773258)
dc.contributor.authorThomas, Sarah A. (55268048900)
dc.contributor.authorRakic, Ljubisa M. (35580670800)
dc.date.accessioned2025-07-02T12:54:51Z
dc.date.available2025-07-02T12:54:51Z
dc.date.issued2001
dc.description.abstractThe brain efflux of radiolabelled hypoxanthine in the rat was rapid in the first minute after injection [Keff(i)=0.21±0.06 min-1], which was saturable with a Vmax=13.08±0.81 nM min-1 g-1, and a high Km.app (67.2±13.4 μM); the Ki.app for inosine was 31.5±7.6 μM. Capillary depletion analysis indicated that hypoxanthine accumulates in neurons and glia with the time. From cross-inhibition studies with different purines and pyrimidines, it suggests that these molecules could also be important substrates for this carrier. © 2001 Elsevier Science B.V.
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(01)02115-1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035957776&doi=10.1016%2fS0006-8993%2801%2902115-1&partnerID=40&md5=6d5067a91f1ef0e14803efbf27a49f78
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14510
dc.subjectBlood-brain barrier
dc.subjectBrain efflux
dc.subjectBrain efflux index
dc.subjectHypoxanthine
dc.subjectNucleobase
dc.titleThe kinetics of hypoxanthine efflux from the rat brain
dspace.entity.typePublication

Files

Collections

Publikacije / Publications