THE EFFECTS OF TWO PHENYLACETIC ACID DERIVATIVES ON THE ANALGESIC ACTION OF MORPHINE IN MICE

Abstract

After intracerebral injection in mice, the analgesic effect of morphine depended on the dose. Two phenylacetic acid esters, CFT 1201 (diethylaminoethylphenyldiallyl acetate) and CFT 1208 (diethylaminoethylphenylallyl acetate), injected intraperitoneally, potentiated the analgesic action of 0·5 μg. of morphine, injected into the posterior portion of the brain 90 min. later. When the phenyl acetates were injected (50 μg.) into the brain, they potentiated the analgesic action of morphine, injected subcutaneously (10 mg./kg.) 80 min. later. The results show that the inhibitors of the hepatic microsomal enzymes may affect the action of analgesics by an action on the central nervous system. 1963 Royal Pharmaceutical Society of Great Britain