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Methylenetetrahydrofolate reductase and glutathione s-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: A case report

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dc.contributor.authorSkoric, Dejan (6602687814)
dc.contributor.authorIvana, Joksic (55908293200)
dc.contributor.authorTanja, Radic (55908247900)
dc.contributor.authorJovana, Jakovljevic (55908583800)
dc.contributor.authorPetar, Ivanovski (55908880500)
dc.contributor.authorTatjana, Simic (55909059900)
dc.date.accessioned2025-06-12T20:43:50Z
dc.date.available2025-06-12T20:43:50Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy. OBSERVATION: We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia. CONCLUSIONS: Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. © 2014 by Lippincott Williams & Wilkins.
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000000050
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84897474017&doi=10.1097%2fMPH.0000000000000050&partnerID=40&md5=897e0e60abdafe0d469708372aef061f
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/8885
dc.subjectgene polymorphism
dc.subjectglutathione S-transferase
dc.subjectmethylenetetrahydrofolate reductase
dc.subjectMixed phenotype acute leukemia
dc.titleMethylenetetrahydrofolate reductase and glutathione s-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: A case report
dspace.entity.typePublication

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