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Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis

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dc.contributor.authorFissolo, Nicolas (6506394852)
dc.contributor.authorCervera-Carles, Laura (56584427900)
dc.contributor.authorVillar Guimerans, Luisa María (35518965300)
dc.contributor.authorLleó, Alberto (6701565311)
dc.contributor.authorClarimón, Jordi (57195450094)
dc.contributor.authorDrulovic, Jelena (55886929900)
dc.contributor.authorDujmovic, Irena (6701590899)
dc.contributor.authorVoortman, Margarete (57195917900)
dc.contributor.authorKhalil, Michael (55628524072)
dc.contributor.authorGil, Elia (57202948532)
dc.contributor.authorNavarro, Laura (56605347700)
dc.contributor.authorÁlvarez-Cermeño, Jose Carlos (7004605927)
dc.contributor.authorMontalban, Xavier (7007177960)
dc.contributor.authorComabella, Manuel (6701491362)
dc.date.accessioned2025-06-12T15:03:03Z
dc.date.available2025-06-12T15:03:03Z
dc.date.issued2019
dc.description.abstractThe role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice. © The Author(s), 2018.
dc.identifier.urihttps://doi.org/10.1177/1352458518786055
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049910149&doi=10.1177%2f1352458518786055&partnerID=40&md5=3bbfecc02e56ada2120ca1e5f2780dd3
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/5449
dc.subjectcerebrospinal fluid
dc.subjectdroplet digital PCR
dc.subjectMitochondrial DNA
dc.subjectmultiple sclerosis
dc.titleCerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis
dspace.entity.typePublication

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