Publication:
Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma

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dc.contributor.authorSobot, Vesna (57353220400)
dc.contributor.authorStamenkovic, Miroslav (7003436370)
dc.contributor.authorSimic, Tatjana (6602094386)
dc.contributor.authorJerotic, Djurdja (57209718540)
dc.contributor.authorDjokic, Milica (57215827890)
dc.contributor.authorJaksic, Vesna (23667666000)
dc.contributor.authorBozic, Marija (26640219200)
dc.contributor.authorMilic, Jovan (57353449700)
dc.contributor.authorSavic-Radojevic, Ana (16246037100)
dc.contributor.authorDjukic, Tatjana (36193753800)
dc.date.accessioned2025-06-12T13:12:46Z
dc.date.available2025-06-12T13:12:46Z
dc.date.issued2022
dc.description.abstractIt is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase (SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102 POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination, GSTO1/GSTO2, modulate the risk of primary open angle glaucoma. © 2021 Elsevier Ltd
dc.identifier.urihttps://doi.org/10.1016/j.exer.2021.108863
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85119902102&doi=10.1016%2fj.exer.2021.108863&partnerID=40&md5=ee8b235d13d141a9cd78f8355b98795f
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/3918
dc.subjectGlutathione peroxidase 1
dc.subjectGlutathione transferases omega 1
dc.subjectGlutathione transferases omega 2
dc.subjectGlutathione transferases pi 1
dc.subjectPrimary open angle glaucoma
dc.subjectSuperoxide dismutase 2
dc.titleAssociation of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma
dspace.entity.typePublication

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