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Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine

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dc.contributor.authorStepanović-Petrović, Radica M. (6506683297)
dc.contributor.authorTomić, M.A. (7006939166)
dc.contributor.authorVučković, S.M. (7003869333)
dc.contributor.authorUgrešić, N.D. (6602152735)
dc.contributor.authorProstran, M.Š. (7004009031)
dc.contributor.authorBošković, B. (7004055023)
dc.date.accessioned2025-07-02T12:49:45Z
dc.date.available2025-07-02T12:49:45Z
dc.date.issued2007
dc.description.abstractThe mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, on the antihyperalgesic effects of carbamazepine and oxcarbazepine were examined in the model of inflammatory hyperalgesia induced by the intraplantar (i.pl.) administration of concanavaline A (Con A, 0.8 mglpaw) into the rat hind paw. Naloxone (3 mglkg; i.p.) did not alter the antihyperalgesic effects of either carbamazepine or oxcarbazepine. These results indicate that the opioid system of pain modulation does not play a significant role in the antihyperalgesic effects of carbamazepine and oxcarbazepine. © 2007 Prous Science. All rights reserved.
dc.identifier.urihttps://doi.org/10.1358/mf.2007.29.3.1075352
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34250353535&doi=10.1358%2fmf.2007.29.3.1075352&partnerID=40&md5=a6a28b37a899e140b5513d31149761f3
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14328
dc.subjectCarbamazepine
dc.subjectInflammatory hyperalgesia
dc.subjectNaloxone
dc.subjectOpioid receptors
dc.subjectOxcarbazepine
dc.titleOpioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine
dspace.entity.typePublication

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