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The β-blocker uptitration in elderly with heart failure regarding biomarker levels: CIBIS-ELD substudy

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dc.contributor.authorCvetinovic, Natasa (55340266600)
dc.contributor.authorSekularac, Nikola (23981224200)
dc.contributor.authorHaehling, Stephan Von (6602981479)
dc.contributor.authorTahirovic, Elvis (24339336300)
dc.contributor.authorInkrot, Simona (35784615000)
dc.contributor.authorLainscak, Mitja (9739432000)
dc.contributor.authorApostolovic, Svetlana (13610076800)
dc.contributor.authorPutnikovic, Biljana (6602601858)
dc.contributor.authorWaagstein, Finn (56216780700)
dc.contributor.authorGelbrich, Goetz (14119833600)
dc.contributor.authorAleksic, Andja (57206730766)
dc.contributor.authorLoncar, Goran (55427750700)
dc.contributor.authorDüngen, Hans-Dirk (16024171900)
dc.date.accessioned2025-06-12T16:46:03Z
dc.date.available2025-06-12T16:46:03Z
dc.date.issued2018
dc.description.abstractAim: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure. Patients & methods: According to the biomarkers’ levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. Results: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of β-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. Conclusion: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration. C 2018 Future Medicine Ltd
dc.identifier.urihttps://doi.org/10.2217/bmm-2018-0136
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85061910845&doi=10.2217%2fbmm-2018-0136&partnerID=40&md5=bcdda3105b23ef21634afba107ba2095
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/6599
dc.subjectChronic heart failure
dc.subjectCopeptin
dc.subjectMid-regional pro-atrial natriuretic peptide
dc.subjectN-terminal pro B-type natriuretic peptide
dc.subjectΒ-blocker uptitration
dc.titleThe β-blocker uptitration in elderly with heart failure regarding biomarker levels: CIBIS-ELD substudy
dspace.entity.typePublication

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