Premature Ovarian Failure: Fertility Challenge

Abstract

Premature ovarian insufficiency (POI) (also known as premature menopause) is a heterogeneous disorder of multifactorial origin defined as the occurrence of secondary amenorrhoea, hypergonadotropism (follicle-stimulating hormone above 40 IU/L) and hypoestrogenism (oestradiol below 50 pmol/L) in women under the age of 40 years. © 2015, International Society of Gynecological Endocrinology.