Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease

Abstract

AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD). METHODS: The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34). Who Were Referred to Our Neurocardiology Lab. at the Clin. and Hosp. Ctr. bezanijska Kosa with A Diagn. of GERD. One Hundred Sixteen Healthy Volunteers Matched in Age and Sex with the Examinees Served As the Contr. Grp.. the Stud. Protocol Included the Eval. of Autonomic Funct. and Hemodynamic Status, Short-term Heart Rate Variability Anal., 24 H Ambulatory ECG Monitoring with Long-term HRV Anal. and 24 H Ambulatory Blood Pressure Monitoring. RESULTS: Pathologic Results of Cardiovasc. Reflex Test Were More Com. among Patients with Reflux Compared to the Contr. Grp.. Severe Autonomic Dysfunction Was Detected in 44.4% of Patients and in 7.9% of Controls . Parameters of Short-term Anal. of RR Variability, Which Are the Indicat. of Vagal Activ., Had Lower Values in Patients with GERD Than in the Contr. Grp.. Long-term HRV Anal. of Time-domain Parameters Indicated Lower Values in Patients with Reflux Dis. When Compared to the Contr. Grp.. Pwr. Spectral Anal. of Long-term HRV Revealed Lower Low-and High-frequency Values. Detailed 24 H Ambulatory Blood Pressure Anal. Showed Significantly Higher Values of Systolic Blood Pressure and Pulse Pressure in the Reflux Grp. Than in the Contr. Grp.. CONCLUSION: Patients with GERD Have Distortion of Sympathetic and Parasympathetic Components of the Autonomic Nerv. Syst., but Impaired Parasympathetic Funct. Appears More Congruent to GERD. 2015 Baishideng Publ. Grp. Inc. All Rights Reserved.