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IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

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dc.contributor.authorMalhotra, S. (50262475300)
dc.contributor.authorMorcillo-Suárez, C. (24465436500)
dc.contributor.authorBrassat, D. (55666405000)
dc.contributor.authorGoertsches, R. (55882530700)
dc.contributor.authorLechner-Scott, J. (6603311349)
dc.contributor.authorUrcelay, E. (10639601200)
dc.contributor.authorFernández, O. (7102560044)
dc.contributor.authorDrulovic, J. (55886929900)
dc.contributor.authorGarcía-Merino, A. (6602178754)
dc.contributor.authorMartinelli Boneschi, F. (57202042750)
dc.contributor.authorChan, A. (7403168324)
dc.contributor.authorVandenbroeck, K. (7003943780)
dc.contributor.authorNavarro, A. (35477108400)
dc.contributor.authorBustamante, M.F. (36647223700)
dc.contributor.authorRío, J. (7006734684)
dc.contributor.authorAkkad, D.A. (12787505100)
dc.contributor.authorGiacalone, G. (37037407500)
dc.contributor.authorSánchez, A.J. (37665880200)
dc.contributor.authorLeyva, L. (6602303467)
dc.contributor.authorAlvarez-Lafuente, R. (13411081600)
dc.date.accessioned2025-07-02T12:41:04Z
dc.date.available2025-07-02T12:41:04Z
dc.date.issued2011
dc.description.abstractRecent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. © 2011 Elsevier B.V.
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2011.08.004
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-80054889075&doi=10.1016%2fj.jneuroim.2011.08.004&partnerID=40&md5=5959276bc93234a90da4b456120d0fea
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14003
dc.subjectInterferon-beta
dc.subjectMultiple sclerosis
dc.subjectPolymorphisms
dc.subjectResponse
dc.titleIL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis
dspace.entity.typePublication

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