Publication: Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies
| dc.contributor.author | Lazarević, Milica (57204644899) | |
| dc.contributor.author | Djedovic, Neda (54902044600) | |
| dc.contributor.author | Stanisavljević, Suzana (56545525300) | |
| dc.contributor.author | Dimitrijević, Mirjana (56268210300) | |
| dc.contributor.author | Stegnjaić, Goran (57222587368) | |
| dc.contributor.author | Krishnamoorthy, Gurumoorthy (14421017300) | |
| dc.contributor.author | Mostarica Stojković, Marija (6701741422) | |
| dc.contributor.author | Miljković, Đorđe (7006524033) | |
| dc.contributor.author | Jevtić, Bojan (57191532541) | |
| dc.date.accessioned | 2025-06-12T13:33:10Z | |
| dc.date.available | 2025-06-12T13:33:10Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Experimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple sclerosis model. Here, we compare clinical, cellular and molecular properties between syngeneic spinal cord homogenate (SCH)- and SCH + CFA-immunized Dark Agouti rats. EAE signs were observed earlier and the cumulative clinical score was higher without CFA. Also, a higher number of immune cells infiltrates in the spinal cords was noticed at the peak of EAE without CFA. High spinal cord abundance of CD8+CD11bc+MHC class II+ cells was detected in SCH-immunized rats. Myelin basic protein -specific response can be elicited in the cells from the lymph nodes draining the site of SCH immunization. This CFA-free EAE is a reliable multiple sclerosis model. © 2021 Elsevier B.V. | |
| dc.identifier.uri | https://doi.org/10.1016/j.jneuroim.2021.577547 | |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103341915&doi=10.1016%2fj.jneuroim.2021.577547&partnerID=40&md5=182727cf38d2ec0e84153282ca5418f2 | |
| dc.identifier.uri | https://remedy.med.bg.ac.rs/handle/123456789/4213 | |
| dc.subject | CD4<sup>+</sup> T cells | |
| dc.subject | CD8<sup>+</sup> macrophages | |
| dc.subject | CFA | |
| dc.subject | EAE | |
| dc.title | Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies | |
| dspace.entity.type | Publication |