Publication: Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium
| dc.contributor.author | Du, Qingyou (14035606200) | |
| dc.contributor.author | Jovanović, Sofija (57194064227) | |
| dc.contributor.author | Tulić, Lidija (6504063680) | |
| dc.contributor.author | Tulić, Ivan (6602743219) | |
| dc.contributor.author | Jovanović, Aleksandar (7006571994) | |
| dc.date.accessioned | 2025-06-12T14:56:35Z | |
| dc.date.available | 2025-06-12T14:56:35Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH. © 2019 International Society for the Study of Hypertension in Pregnancy | |
| dc.identifier.uri | https://doi.org/10.1016/j.preghy.2019.09.008 | |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072729690&doi=10.1016%2fj.preghy.2019.09.008&partnerID=40&md5=c779b8a0512ada1f151310dc46c80e68 | |
| dc.identifier.uri | https://remedy.med.bg.ac.rs/handle/123456789/5373 | |
| dc.subject | ATP-sensitive K<sup>+</sup> channels | |
| dc.subject | PIH | |
| dc.subject | Uterus | |
| dc.title | Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium | |
| dspace.entity.type | Publication |