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Severe transient left ventricular pseudohypertrophy during treatment of hemophagocytic lymphohistiocytosis: A case report

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dc.contributor.authorKuzmanovic, Milos (6602721300)
dc.contributor.authorPasic, Srdjan (55904557400)
dc.contributor.authorPrijic, Sergej (20734985500)
dc.contributor.authorJovanovic, Ankica (26026335200)
dc.contributor.authorKosutic, Jovan (55928740700)
dc.date.accessioned2025-06-12T22:00:19Z
dc.date.available2025-06-12T22:00:19Z
dc.date.issued2012
dc.description.abstractBackground: An association between hemophagocytic lymphohistiocytosis (HLH) and severe transient left ventricular (LV) hypertrophy has not been described to date. Possible explanations, including etoposide toxicity, are discussed. Observation: A 2-month-old male infant with HLH was treated according to the HLH-2004 protocol. Initial cardiac evaluation was within normal limits. During the second month of therapy, a heart murmur was discovered; electrocardiogram demonstrated signs of LV hypertrophy, and echocardiogram confirmed the presence of thickness of LV walls. This complication was transient: clinical findings, echocardiogram, and electrocardiogram recorded 6 months afterward were all within normal limits. Conclusions: The case suggests the need for close echocardiographic monitoring during HLH treatment. Copyright © 2012 by Lippincott Williams & Wilkins.
dc.identifier.urihttps://doi.org/10.1097/MPH.0b013e318257a4cb
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84864337008&doi=10.1097%2fMPH.0b013e318257a4cb&partnerID=40&md5=1e247f2f672ada8128abef762e34f203
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/9648
dc.subjecthemophagocytic lymphohistiocytosis
dc.subjectinfant
dc.subjectleft ventricular pseudohypertrophy
dc.titleSevere transient left ventricular pseudohypertrophy during treatment of hemophagocytic lymphohistiocytosis: A case report
dspace.entity.typePublication

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