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The importance of minimal residual disease for detection of late relapse in B-precursor acute lymphoblastic leukemia

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dc.contributor.authorVirijevic, Marijana (36969618100)
dc.contributor.authorKraguljac-Kurtovic, N. (37037758700)
dc.contributor.authorPantic, N. (57221630977)
dc.contributor.authorKnezevic, V. (56806620700)
dc.contributor.authorMitrovic, M. (54972086700)
dc.date.accessioned2025-06-12T13:00:21Z
dc.date.available2025-06-12T13:00:21Z
dc.date.issued2022
dc.description.abstractBackground: The minimal residual disease (MRD) level in patients with B-precursor acute lymphoblastic leukemia (B-ALL) is the strongest independent predictor of relapse and survival. Assessment of MRD plays a crucial role in the treatment of B-ALL. Case report: We performed long-term monitoring of a 30-year-old woman with B-ALL of standard risk for MRD using multiparametric flow cytometry (MFC). After five years of monitoring, molecular relapse of the disease was confirmed. Conclusion: This case illustrates that more extended monitoring for MRD, even by only MFC when other newer so-phisticated diagnostics are not available, is essential in detecting early relapse in patients with B-ALL of standard risk. © 2022, Lithografia Antoniadis I - Psarras Th G.P.. All rights reserved.
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85158084403&partnerID=40&md5=17b385cd2633b2b3edde3d712d46e6ad
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/3711
dc.subjectB-precursor acute lymphoblastic leukemia
dc.subjectlate relapse
dc.subjectMinimal residual disease
dc.subjectmultiparametric flow cytometry
dc.titleThe importance of minimal residual disease for detection of late relapse in B-precursor acute lymphoblastic leukemia
dspace.entity.typePublication

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