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Correlation between triplet repeat expansion and computed tomography measures of caudate nuclei atrophy in Huntington's disease

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dc.contributor.authorCuljkovic, Biljana (37033675400)
dc.contributor.authorStojkovic, Oliver (35618950700)
dc.contributor.authorVojvodic, Nikola (6701469523)
dc.contributor.authorSvetel, Marina (6701477867)
dc.contributor.authorRakic, Ljubisa (35580670800)
dc.contributor.authorRomac, Stanka (7003983993)
dc.contributor.authorKostic, Vladimir (35239923400)
dc.date.accessioned2025-07-02T12:54:19Z
dc.date.available2025-07-02T12:54:19Z
dc.date.issued1999
dc.description.abstractHuntington's disease (HD) is an autosomal dominant, progressive disorder characterized by choreic movements, cognitive decline, and psychiatric manifestations. Eleven patients with HD were retrospectively selected from a larger group of 42 patients based on the similar, early onset of the disease (between 21 and 30 years) and the same duration of HD at the moment of computed tomography (CT) examination (5 years). A significant correlation between the number of CAG trinucleotides and the bicaudate index or the frontal horn index, two indices of caudate atrophy, was found in this group of patients. Our results, although in a small number of patients, suggest that the striatal degeneration, assessed by CT measures, is primarily regulated by the size of expanded CAG repeats.
dc.identifier.urihttps://doi.org/10.1007/s004150050518
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0032750061&doi=10.1007%2fs004150050518&partnerID=40&md5=879bb86983d74361e0728282c1620f8e
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/14490
dc.subjectCAG repeats
dc.subjectCaudate atrophy
dc.subjectComputed tomography
dc.subjectHuntington's disease
dc.titleCorrelation between triplet repeat expansion and computed tomography measures of caudate nuclei atrophy in Huntington's disease
dspace.entity.typePublication

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