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Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: Case report and review of literature

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dc.contributor.authorJurisic, Vladimir (6603015144)
dc.contributor.authorColovic, Natasa (6701607753)
dc.contributor.authorTerzic, Tatjana (55916182400)
dc.contributor.authorDjordjevic, Vesna (57215460423)
dc.contributor.authorColovic, Milica (21639151700)
dc.date.accessioned2025-07-02T12:40:35Z
dc.date.available2025-07-02T12:40:35Z
dc.date.issued2012
dc.description.abstractA 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia. © 2012 Elsevier GmbH.
dc.identifier.urihttps://doi.org/10.1016/j.prp.2012.04.007
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84863815856&doi=10.1016%2fj.prp.2012.04.007&partnerID=40&md5=7e970f53002ec896364782288a1d67a1
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/13985
dc.subject20q-
dc.subjectALL
dc.subjectCytogenetics
dc.subjectImmunophenotype
dc.subjectMutation
dc.subjectMyelofibrosis
dc.subjectPhiladelphia chromosome
dc.subjectTransformation
dc.titleTransformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: Case report and review of literature
dspace.entity.typePublication

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