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The occurrence of oligoclonal IgG in tears from patients with MS and systemic immune disorders

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dc.contributor.authorMavra, M. (6701398727)
dc.contributor.authorThompson, E.J. (7402849206)
dc.contributor.authorNikolic, J. (57200047847)
dc.contributor.authorKrunic, A. (7003358776)
dc.contributor.authorRanin, J. (6603091043)
dc.contributor.authorLevic, Z. (7003341242)
dc.contributor.authorKeir, G. (7003356165)
dc.contributor.authorLuxton, R. (9741127500)
dc.contributor.authorYoul, B.D. (56696920500)
dc.date.accessioned2025-06-12T11:55:14Z
dc.date.available2025-06-12T11:55:14Z
dc.date.issued1990
dc.description.abstractUsing isoelectric focusing (IEF) and immunoperoxidase staining of proteins transferred to nitrocellulose membranes, we have examined the IgG band pattern in tears and matched serum and CSF specimens of 28 patients with MS, 4 patients with optic neuritis (ON), 30 individuals with systemic, inflammatory, or other neurologic diseases, and 5 patients with tension headache. We found no evidence of positive oligoclonal IgG in tears in any MS or ON patients, while 10 out of 16 cases with systemic immune disorders or infections of the CNS had positive tear oligoclonal bands. We are thus not able to support the hypothesis that tears from MS patients reveal abnormalities in their humoral immune response. © 1990 American Academy of Neurology.
dc.identifier.urihttps://doi.org/10.1212/wnl.40.8.1259
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0025179001&doi=10.1212%2fwnl.40.8.1259&partnerID=40&md5=c01156651dd299ce2d0d30f7498000f0
dc.identifier.urihttps://remedy.med.bg.ac.rs/handle/123456789/1857
dc.titleThe occurrence of oligoclonal IgG in tears from patients with MS and systemic immune disorders
dspace.entity.typePublication

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