Chromosomes and fertility translocation 13:15 and 13:18 and spontaneous abortion

Abstract

Cytogenetic investigations of three married couples, having had spontaneous abortions, was carried out, and an abnormal chromosomal complement was established in one of the spouses. The balanced translocations were of the types: 13/15 (q14:126) and 13/18 (q34:q11). The same type of translocations 13/18 (q24:q11) was detected in two other couples. The translocation carriers are brother and sister. In the cases examined the balanced translocations were causes of spontaneous abortions and the birth of malformed children. According to the accessible literature data, translocations with the above-mentioned breaks on chromosomes have not been discovered until now.