Publication: Estradiol in vivo induces changes in cardiomyocytes size in obese rats
| dc.contributor.author | Obradovic, Milan (48061421600) | |
| dc.contributor.author | Sudar, Emina (23570110000) | |
| dc.contributor.author | Zafirovic, Sonja (55697604900) | |
| dc.contributor.author | Stanimirovic, Julijana (56441699200) | |
| dc.contributor.author | Labudovic-Borovic, Milica (36826154300) | |
| dc.contributor.author | Isenovic, Esma R. (14040488600) | |
| dc.date.accessioned | 2025-06-12T19:51:34Z | |
| dc.date.available | 2025-06-12T19:51:34Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 μg/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy via Akt. © The Author(s) 2013. | |
| dc.identifier.uri | https://doi.org/10.1177/0003319713514477 | |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927172355&doi=10.1177%2f0003319713514477&partnerID=40&md5=a79b584373ae42d87a16fcb1f17515f9 | |
| dc.identifier.uri | https://remedy.med.bg.ac.rs/handle/123456789/8365 | |
| dc.subject | Cardiac hypertrophy | |
| dc.subject | Estradiol | |
| dc.subject | IR | |
| dc.subject | Obesity | |
| dc.title | Estradiol in vivo induces changes in cardiomyocytes size in obese rats | |
| dspace.entity.type | Publication |