Browsing by Subject ""Lone""

Background-The CHA 2DS 2-VASc (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke/transient ischemic attack [TIA], Vascular disease, Age 65-74 years, and Sex category [female gender]) schema recently has been introduced to complement the CHADS 2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, and previous stroke or TIA) score and improve the identification of atrial fibrillation (AF) patients at "truly low risk" for thromboembolism. We tested the predictive ability of the CHA 2DS 2-VASc, CHADS 2, and van Walraven risk stratification schemes in a cohort of "lone" AF patients with a 12-year follow-up. Methods and Results-We conducted a registry-based, observational cohort study of 345 patients initially diagnosed with "lone" AF between 1992 and 2007. At baseline, all patients had the CHADS 2 and van Walraven scores of 0, and 262 (75.9%) had a CHA 2DS 2-VASc score of 0. During follow-up (or within a year prior to stroke), 228 (66.1%), 234 (67.8%), and 150 patients (43.5%) retained the CHADS 2, van Walraven, and CHA 2DS 2-VASc scores of 0, respectively. The overall rate of ischemic stroke was 0.19 (95% CI: 0.18-0.20) per 100 patient years. In the multivariable analysis, only the CHA 2DS 2-VASc score of 0 was significantly related to the absence of stroke (odds ratio 5.1, 95% CI: 1.5-16.8, P=0.008). Only the CHA 2DS 2-VASc score had a significant prediction ability (c-statistic 0.72 [0.61- 0.84], P<0.031). Conclusions-The CHA 2DS 2-VASc score reliably identified the "lone" AF patients who were at "truly low risk" for thromboembolism, and was the only tested risk stratification scheme with a significant predictive ability for thromboembolism among lone AF patients. © 2012 American Heart Association, Inc.