Browsing by Author "Zdravkovic, M. (57826401000)"

Objectives Regular endurance training in athletes is associated with a higher maximal oxygen uptake (VO2max), a lower body fat percentage (BF%), and improved blood pressure (BP) control. However, are those adaptive changes present in athletes with higher BF%, has not been previously examined. This study aimed to evaluate the influence of the body composition to the resting and maximal BP values and cardiorespiratory functional capacity in elite athletes. Equipment and methods A total of 194 men elite athletes were examined. According to World Health Organization recommendation, athletes were divided according to BF% in 3 groups: low: ≤ 8, optimal: 9–19%, overweight: ≥ 20%. Anthropometric measurements, resting systolic (SBP) and diastolic (DBP) pressures were measured. VO2max and maximal BP were directly measured by maximal graded exercise test on treadmill until exhaustion. Results Seventy-six (39%) athletes had low BF%, 107 (55%) had optimal BF%, while 11 (5%) athletes had BF% in overweight category. The incidence of hypertension (SBP ≥ 140 and/or DBP ≥ 90 mmHg) was 4% in low BF%, 6% in optimal and 21% in the overweight group. Athletes in overweight category had significantly higher resting SBP and DBP values, and maximal DBP and lower VO2max compared to all other athletes (P < 0.001). Recovery DBP was significantly lower in low BF% group compared to all other athletes (P < 0.01). There was statistically significant negative correlation between resting SBP and VO2max values in normal BF% group (r = −0.24; P < 0.001). BF% independently predicted resting BP and HR, as well as maximal DBP and VO2max, while BMI independently predicted only maximal HR and resting DBP (P < 0.001). Optimal body composition in athletes is a strong determinant of optimal functional aerobic capacity and resting BP. BF% elevation is strong negative predictive factor for maximal oxygen uptake and resting BP. © 2017 Elsevier Masson SAS

OBJECTIVE: This review analyzes the prevalence of the most important comorbidities associated with atrial fibrillation (AF) in the growing population of patients with Cushing's syndrome (CS). MATERIALS AND METHODS: The review is arranged in a way to list important risk factors for AF and the references, which suggest the significant prevalence of these particular risk factors in CS. The search is conducted on PubMed, Science Direct, Springer, Wiley, SAGE, Oxford Press, and Google Scholar. PubMed search for "Cushing's syndrome atrial fibrillation" on 8/7/2019 revealed 4 papers only. None of them either analyzed or implicated high risk for AF in CS. RESULTS: Arterial hypertension (AHT) can be found in approximately 80% of adult individuals with endogenous CS and in 20% of patients with exogenous CS. The reported prevalence of diabetes mellitus (DM) is from 13% to 47% in CS patients and the risk for de novo DM is approximately two-fold higher in individuals treated with glucocorticoids. High risk for myocardial infarction (MI) with hazard ratio (HR) 3.7 (95% confidence intervals, CI 2.4-5) in patients with endogenous CS was found. In CS patients the obesity can be detected in up to 41% and overweight in 21-48%. Left ventricular hypertrophy (LVH), pulmonary thromboembolism (PTE), infections, and hypokalemia are also more prevalent in CS as compared to healthy population. All cited comorbidities have been associated with AF. Therefore, clustering of the important factors associated with AF is confirmed repeatedly in CS. CONCLUSIONS: The prevalence of AF in CS should be studied more precisely, both in a scientific way and at the individual patient's level. © 2020 Verduci Editore s.r.l. All rights reserved.