Browsing by Author "Zamurović, M. (16065246600)"

Background: This study investigated the correlation between cervical cytology, the expression of P16INK4a, and human papilloma virus (HPV) infection. Materials and Methods: The study included 100 subjects with suspected pathological cervical lesions. Cervical smears were analyzed for malignancy and p16INK4p. Histological finding represented "the golden standard". Results: Immunocytochemical analysis of protein p16INK4a expression on epithelial cells of cervical smear demonstrated increased p16INK4a expression in 36.0% of subjects. There was statistically significant positive correlation (Spearman r = 0.70; p < 0.001) between the pathological findings and the intensity of p16INK4a protein expression inside the epithelial cells, as well as with the histological finding (Spearman r = 0.71; p < 0.001). The intensity of p16INK4a protein expression in cytology finding was significantly higher in HPV16 positive patients (MannWhitney test, p = 0.0065). Conclusion: Good correlation between the expression rate and the severity of lesions indicates that this test might improve the results of cytology and HPV screening, as well as the results of predicting the prognosis of the disorder of the cervix.

Agenesis of the corpus callosum is an uncommon cerebral malformation usually of unknown etiology. It can be associated with other brain abnormalities, such as ventriculomegaly, or in combination with problems with other organs, such as congenital heart defect, as well as with chromosome anomalies. Diagnosis of this rare anomaly is important not only because of possible association with other developmental anomalies but also because of postnatal treatment and evaluation of children with this disorder. This paper presents prenatal diagnosis of partial agenesis of the posterior part of corpus callosum of a fetus detected in gestational week 33 by ultrasonography as an isolated developmental disorder, i.e., not accompanied by other morphological anomalies of the fetus or chromosome aberrations or other genetic defects.