Browsing by Author "Vujošević, Snežana (6603110578)"

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Editorial on prevalence, diagnosis and treatment with 3 different statins of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in military personnel. Do genetics play a role?
(2021)
Muzurović, Emir (57210067673)
;
Smolović, Brigita (56033663200)
;
Vujošević, Snežana (6603110578)
;
Petakov, Milan (7003976693)
[No abstract available]
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Editorial on prevalence, diagnosis and treatment with 3 different statins of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in military personnel. Do genetics play a role?
(2021)
Muzurović, Emir (57210067673)
;
Smolović, Brigita (56033663200)
;
Vujošević, Snežana (6603110578)
;
Petakov, Milan (7003976693)
[No abstract available]
Some of the metrics are blocked by your
consent settings
Parathyroid hormone and calcitonin response during the calcium infusion test in patients with primary hyperparathyroidism
(2022)
Muzurović, Emir (57210067673)
;
Tomšić, Karin Zibar (57219877854)
;
Vujošević, Snežana (6603110578)
;
Petakov, Milan (7003976693)
Objective: While activation of the calcium (Ca) sensing receptor (CaSR) suppresses parathyroid hormone (PTH) secretion, calcitonin (CT) secretion is stimulated via CaSR. The aim of this study was to evaluate PTH and CT responses during a calcium infusion test (CIT) in patients with primary hyperparathyroidism (PHPT). Methods: This pivotal prospective study included 64 patients (44 PHPT patients vs. 20 healthy controls [HCs], median age 57 [25–79] vs. 56 [39–74] years). All PHPT patients underwent parathyroidectomy (PTX). A week before and 1 month after PTX, the CIT was performed (bolus infusion of Ca gluconate 0.2 ml/kg body weight), followed by plasma sampling for Ca2+, PTH, and CT at 0, 1, 2, 3, 5, 8, and 10 min. Results: PTH suppression was lower in PHPT patients compared to HCs (49.82 vs. 64.06%, p = 0.006), but after PTX suppression, it was higher (76.3%, p < 0.001). PHPT patients had attenuated CT response vs. HCs during the CIT (3.1- vs. 8.0-fold increase, p < 0.001), but after PTX, it improved (5.8-fold increase). The PTHmin > 19.3 ng/l and CTmax ≤ 27.5 ng/l cut-off values predict diagnosis of PHPT (sensitivity 90.9%, 97.7%, and specificity 100%, 75%, respectively). Patients with adenoma had lower basal CT levels vs. hyperplasia both before and after PTX (4.5 vs. 6.8 and 5.4 vs. 7.9 ng/l, respectively, p = 0.008, p = 0.018). Conclusion: PTH and CT responses during the CIT in PHPT patients may be an additional diagnostic tool. The CIT could play a role in both the diagnosis of PHPT and in the differential diagnosis between adenoma and hyperplasia. © 2022, Hellenic Endocrine Society.