Browsing by Author "Vlajinac, H.D. (7006581450)"

Objectives: This study aims to investigate whether overweight and obesity are related to the clinical (C) category of clinical, etiologic, anatomic and pathophysiologic (CEAP) classification of chronic venous disease (CVD). Design: A cross-sectional study. Materials and methods: The study was conducted in Serbia, in the year 2011. Men and women aged >18 years, consecutively coming to venous specialists because of venous problems in the legs, were included in the study. Patients demographic, anthropometric and clinical data were collected. For the analysis, univariate and multivariate logistic regressions were used. Results: The study comprised 1116 subjects with primary CVD, 384 (34.4%) men and 732 (65.6%) women. Among them 464 (41.6%) were normal-weight patients (body mass index (BMI) < 25.0 kg m-2), 476 (42.7%) were overweight (BMI = 25.0-29.9 kg m-2) and 176 (15.8%) were obese (BMI ≥ 30.0 kg m-2). According to multivariate analysis, the CEAP C category of CVD was significantly more advanced in overweight and obese patients, the association being more pronounced in obese. Compared groups did not differ in the presence of venous reflux. In univariate analysis, venous obstruction was related to overweight and obesity but this association did not substantially affect the relationship between obesity and CEAP C categories of CVD. Conclusion: The CEAP C categories of CVD were significantly related to overweight and obesity, and this association was independent of age, sex and some other postulated risk factors.© 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Study objective - To determine trends in cardiovascular disease mortality. Design - This was a descriptive study analysing mortality data. Setting - Belgrade, Yugoslavia. Participants - The population of Belgrade in the age group 30-69 years was studied (about 760 000 inhabitants). Measurements - Mortality rates were standardised directly using those of the 'European population' as the standard, and regression analysis was undertaken. Main results - Between 1975 and 1989 'all causes' mortality increased by 27% (95% confidence interval 18.5, 35.9) in men and by 19% (11.6, 27.1) in women. The increase in cardiovascular disease mortality was 7% (1.7, 11.5) for men and 4% (0.2, 7.8) for women. Mortality from ischaemic heart disease fell in both sexes by 32% (23.0, 41.0), but mortality from other heart diseases rose by 31% (22.0, 40.2) in men and 25% (16.2, 33.0) in women. In men the death rate for cerebrovascular disease increased by 37% (27.8, 46.8), but in women the rate fell by 0.4% (-0.8, 1.6). Mortality from the observed causes of death was higher in men than in women. Conclusion - Cardiovascular mortality trends in Belgrade are similar to those in most eastern European countries. If the distribution of cigarette smoking and a 'rich' diet in the Belgrade population is taken into account, a considerable decline in cardiovascular mortality trends cannot be expected in the near future.

The case-control study was conducted in Belgrade (Yugoslavia) during the period 1994-1998. The objective of the study was to investigate factors related to the occurrence of multiple myeloma (MM). The study group consisted of 100 newly diagnosed MM patients and the same number of matched hospital controls. In the analysis conditional univariate and multivariate logistic regression were applied. According to multivariate analysis the following factors were significantly related to MM: smoking ≥25 cigarettes per day (Odds ratio- OR=6.7, 95% confidence interval-95% CI=1.3-34.3); having more than two brothers (OR=2.7, 95% CI=1.3-5.3), rheumatoid arthritis in personal history (OR=4.2, 95% CI=1.2-14.8), and frequent (4-7 times per week vs. lower frequency) consumption of yogurt (OR=3.1 95% CI=1.6-6.0) and vegetables (OR=0.4, 95% CI=0.1-1.0).

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In this study, we investigated whether the occurrence and intensity of leg pain are related to C class of the clinical, etiological, anatomical, and pathophysiological (CEAP) classification for chronic venous disease (CVeD). This cross-sectional study, conducted in Serbia, included 2841 patients: 2027 (71.3%) women and 814 (28.7%) men with CVeD diagnosed by general practitioners. For the first time, the Numeric Rating Scale of 0 to 5 units was used to assess the intensity of pain. For the analysis, univariate and multivariate logistic and linear regressions were applied. Pain in the legs was reported by 90.5% of the patients. The occurrence of pain significantly (P <.001) increased with increasing C class. Of the patients who reported pain in the legs, 42.0% had moderate pain, 23.7% had moderate to severe pain, 22.8% had light pain, 11.2% had severe pain, and 0.3% had very severe pain. Severity of pain differed significantly (P <.001) according to C class. Light and moderate pain gradually decreased and severe pain gradually increased from C0 to C6 class. These associations remained significant after adjustment for age, body mass index, and family history of CVeD. © SAGE Publications.

The aim of this study was to assess the risk factors for basal cell carcinoma (BCC). A case-control study, carried out in two towns in Yugoslavia, comprised 200 BCC cases and 399 controls. For statistical analysis, univariate and multivariate logistic regressions were used. The risk factors found for BCC were: freckling before the age 15, seven or more weeks per year spent at the seaside during holidays (lifetime average), outdoor work during summer-time, occupational exposure to organic and non-organic dissolvents and organophosphatic compounds, use of tar for cosmetic purposes, and previous BCC in personal history. Subjects who tended to burn and not to tan after sun exposure also showed a significantly higher risk for BCC. Brown eyes and history of acne had a protective effect. This study confirmed the role of both constitutional and environmental factors in the development of BCC.

Background: Thyroid cancer is relatively rare, but it is the most frequent cancer among malignancies of the endocrine system. To evaluate the association between thyroid cancer and potential risk factors. Material and methods: A case-control study was conducted in Central Serbia, Yugoslavia. The case group consisted of 100 newly diagnosed patients with histologically confirmed thyroid cancer. The controls (100 patients with injuries) were individually matched with cases by sex, age and place of residence. McNemar's test and conditional logistic regression were used in the analysis. Results: According to logistic regression analysis the following factors were independently related with the occurrence of thyroid cancer: diagnostic X- ray during childhood and/or youth goiter, history of residence in endemic goiter area, anemia in personal history, history of previous malignant tumors, family history of any malignant tumor, spontaneous abortion and use of oral contraceptives. Conclusion: The present study supports the hypothesis that besides other risk factors, thyroid cancer in women is affected by some reproductive and probably hormonal factors.

Objectives: The purpose of this study is to compare cases with type 2 diabetes and their controls for the frequency of stressful life events and social support before the occurrence of the disease. Methods: The study of cases and their controls was undertaken in Belgrade. A case group comprised 179 subjects in whom type 2 diabetes was for the first time diagnosed in the 'Savski Venac' Medical Center during the period 2005-2007 year. The diagnosis was made by a specialist of internal medicine according to criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. For each case two controls were chosen among patients with trauma (fracture, reposition, internal/external fixation) who were treated at the 'Banjica' Institute for Orthopedic-Surgical Diseases during the same period. Cases and controls were matched by sex, age (62 years) and place of residence (Belgrade). Data were collected on demographic characteristics, habits, personal history, stressful life events, social support and family medical history. Results: According to multivariate analysis low social support in personal history, such as relatives/friends help and financial assistance in solving problems, and bad management of monthly income were significantly positively related to type 2 diabetes. However, significantly more controls than cases had no financial insurance in case of urgent need Conclusion: Examine psychosocial factors play a role in the development of type 2 diabetes. © Acta Clinica Belgica 2014.