Browsing by Author "Vlajinac, H. (7006581450)"

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

Purpose: Dietary factors have been suggested as having a major role in the etiology of prostate cancer. The purpose of this study was to investigate whether there are differences in the dietary factors between younger and older men with prostate cancer. Materials and methods: A case-control study was conducted in two towns of Serbia without provinces. The case group consisted of 101 patients with histologically confirmed prostate cancer and the control group of 202 hospital patients with no neoplastic disorders (for each case two controls were chosen). Cases and controls were individualy matched by age (± 2 years), time of hospital admission and place of residence. Univariate and multivariate logistic regression methods were used for result anlayses. Results: After adjustment for a variety of confounding variables, a significant relationship between prostate cancer and vitamin B 12 (odds ratio - OR = 4.77; 95% confidence interval - 95% C.I. = 1.74-13.07) and potassium (OR = 0.18; 95% C.I. = 0.07-0.49) was found in men ≤ 70 years old. In men > 70 years old daily intake of retinol and atocopherol were independently significantly related to prostate cancer (OR = 3.20; 95% C.I. = 1.38-7.43 and OR = 0.42; 95% C.I. = 0.18-0.99, respectively). Conclusion: Differences between younger and older men in the dietary factors related to prostate cancer (retinol and a-tocopherol) are in line with the existing literature data. The relationship of prostate cancer with vitamin B12 and potassium should be corroborated by other authors.

Aim: The aim of the present study was to investigate the association of the body mass index (BMI) and waist circumfe rence (WC) with the radiographic severity of knee osteoar thritis (rKOA) Methods: A cross-sectional study had been applied during this research which included 150 patients diagnosed at the General Hospital in Užice and Health Center in Arilje (Serbia). The study included patients over the age of 50, diagnosed with OA according to The European League Against Rheumatism (EULAR) criteria. Data on social-demographic characteristics, health habits, and personal and family histories of the partici - pants were collected through a specific questionnaire designated for this research. The severity of the disease was assessed pursuant to radiological changes using the Kellgren-Lawrence grading scale (K-L). The state of nou - rishment was assessed according to the BMI and WC. Results: According to multivariate logistic regression analyses, after adjustment for age, sex, marital status, formal education, present occupation, smoking, al - cohol consumption and physical activity; higher grades of rKOA (grade III and grade IV) were significantly related to BMI (p = 0.038) and WC (p < 0.001). The association was much stronger for obesity defined as BMI ≥30 kg/m2 (p = 0.002) and for abdominal obesity - WC > 102 cm in men and > 88 cm in women (p = 0.009). Conclusion: This study showed that obesity defined as BMI ≥30 kg/m2 and abdominal obesity are strongly related to K-L of rKOA, with the associations being of very similar extent.

One thousand and fifty-nine Shigella sonnei strains were submitted to biotyping and colicine typing. Simultaneous use of biotyping and colicine typing may be considered of value in epidemiological tracing.

One thousand and fifty-nine Shigella sonnei strains were submitted to biotyping and colicine typing. Simultaneous use of biotyping and colicine typing may be considered of value in epidemiological tracing.

The objective of the work was to study blood pressure and some anthropometric characteristics in children. The study design included the prevalence study at Belgrade, Serbia and Montenegro. The study comprised 1651 subjects (809 boys and 842 girls) aged 7-14 years, that is, 2.6% of all relevant population. The average levels of systolic and diastolic blood pressures (SBP and DBF) were 113.4/70.3 mmHg in boys and 114.6/71.1 mmHg in girls. High SBP was present in 4.7% of boys and in 5.3% of girls. High DBP was found in 5.6% of boys and in 4.8% of girls. According to multivariate regression analysis, in boys SBP and DBP were significantly associated with age, body mass index (BMI) and subscapular skinfold, SBP was also associated with body weight, and DBP with triceps skinfold. In girls, SBP was significantly related to BMI, suprailiac skinfold and body height, and DBP was significantly associated with BMI, suprailiac and subscapular skinfolds. The results of the present study support the opinion that BMI is a significant predictor of blood pressure in children and point out to suprailiac skinfold in girls as a possible predictor of blood pressure.

The relationship between cardiovascular risk factors and the prevalence of coronary heart disease was examined in 152 Type 2 diabetic patients (65 men, 87 women) aged 35-54 years and in 105 randomly selected control subjects (46 men, 59 women). Coronary heart disease, defined by symptoms and ECG abnormalities, was 1.2 times higher in male and 3.4 times higher in female diabetic patients than in the controls. In logistic regression analysis (including diabetes, age, body mass index, triglycerides, HDL-cholesterol, non-HDL-cholesterol and hypertension) diabetes showed an independent, significant association to coronary heart disease in women, whereas hypertension was independently related to coronary heart disease in men. © 1992 Gustav Fischer.

To determine potentially teratogenic influencies in Belgrade, a group of 113 mothers who gave birth to severely malformed infants and a control group of 195 mothers with normal infants were interviewed using a structured questionnaire. Statistically significant differences between the two groups were found in the mother's family history of congenital malformations (P < 0.05) and the mother's diseases during the pregnancy (P < 0.01). Infections in the first trimester were particularly more prevalent in case mothers (OR = 7.70; P < 0.01). Mothers did not differ significantly according to exposure to organic solvents, supportive therapy during the pregnancy, use of oral contraceptives, or other personal habits. © 1992 Gustav Fischer.

A case-control study including 204 histologically verified female thyroid cancer patients and an equal number of hospital controls individually matched with cases by sex, age (± 2 years), place of residence and time of hospitalization was performed during the period 1996-2000. In the analysis of data, univariate and multivariate conditional logistic regression, methods were applied. According to multivariate analysis, out of hormonal, menstrual and reproductive characteristics, risk factors for thyroid cancer were spontaneous abortions (odds ratio: OR = 1.89, 95% confidence interval (CI) = 1.03-3.50), oral contraceptives use (OR = 2.34, 95% CI = 1.31-4.18) and thyroid enlargement during pregnancy (OR = 16.44, 95% CI = 3.81-70.80). However, none of these three factors remained independently related to thyroid cancer after adjustment for other factors, which were significantly associated with thyroid cancer in the present study (history of residence in endemic goitre area, history of goitre or thyroid nodule, history of other endocrine diseases, radioactive iodine therapy, occupational exposure to various chemicals, family history of thyroid gland diseases and malignant tumours as well as intake of cruciferous vegetables and other vegetables, and consumption of smoked meat and cheese). © 2003 Lippincott Williams & Wilkins.

A case-control study including 204 histologically verified female thyroid cancer patients and an equal number of hospital controls individually matched with cases by sex, age (± 2 years), place of residence and time of hospitalization was performed during the period 1996-2000. In the analysis of data, univariate and multivariate conditional logistic regression, methods were applied. According to multivariate analysis, out of hormonal, menstrual and reproductive characteristics, risk factors for thyroid cancer were spontaneous abortions (odds ratio: OR = 1.89, 95% confidence interval (CI) = 1.03-3.50), oral contraceptives use (OR = 2.34, 95% CI = 1.31-4.18) and thyroid enlargement during pregnancy (OR = 16.44, 95% CI = 3.81-70.80). However, none of these three factors remained independently related to thyroid cancer after adjustment for other factors, which were significantly associated with thyroid cancer in the present study (history of residence in endemic goitre area, history of goitre or thyroid nodule, history of other endocrine diseases, radioactive iodine therapy, occupational exposure to various chemicals, family history of thyroid gland diseases and malignant tumours as well as intake of cruciferous vegetables and other vegetables, and consumption of smoked meat and cheese). © 2003 Lippincott Williams & Wilkins.

One hundred and one patients with histologically confirmed prostate cancer and 202 hospital controls individually matched by age (± 2 years), hospital admittance and place of residence, were interviewed during the period 1990-94 in two towns in central Serbia (Yugoslavia). In an analysis using multivariate logistic regression, the following factors were significantly related to prostate cancer: (1) occupational physical activity during the year preceding the disease [odds ratio (OR) = 3.87, 95% confidence interval (95% CI) = 2.09 - 7.16]; (2) occupational exposure to asbestos, steel, dyes and lacquers, bitumen, pitch, iron, nickel, lead, fertilizer and certain other agents (OR = 2.13, 95% CI = 1.05 - 4.32); (3) nephrolithiasis (OR = 4.52, 95% CI = 1.43 - 15.30); (4) 'other' diseases in medical history such as chronic bronchitis, chronic rheumatic diseases, hypertension, cardiomyopathy, diabetes mellitus, renal diseases, eye diseases and tuberculosis (OR = 3.14, 95% CI = 1.56 - 6.33); (5) a greater number (≤ 3) of brothers [OR = 2.08, 95% CI = 1.35 - 3.22); (6) greater numbers (≤ 8) of sexual partners (OR = 2.24, 95% CI = 1.13 - 4.44). Marital status, age at first marriage, educational level, age at first sexual intercourse, frequency of sexual intercourse, venereal diseases, tonsillectomy, appendectomy, hernia inguinale and hydrocele, anthropometric characteristics, smoking history, sport and recreational activities and family history of prostatic neoplasms were not found to be independently related to prostate cancer.

One hundred and one patients with histologically confirmed prostate cancer and 202 hospital controls individually matched by age (± 2 years), hospital admittance and place of residence, were interviewed during the period 1990-94 in two towns in central Serbia (Yugoslavia). In an analysis using multivariate logistic regression, the following factors were significantly related to prostate cancer: (1) occupational physical activity during the year preceding the disease [odds ratio (OR) = 3.87, 95% confidence interval (95% CI) = 2.09 - 7.16]; (2) occupational exposure to asbestos, steel, dyes and lacquers, bitumen, pitch, iron, nickel, lead, fertilizer and certain other agents (OR = 2.13, 95% CI = 1.05 - 4.32); (3) nephrolithiasis (OR = 4.52, 95% CI = 1.43 - 15.30); (4) 'other' diseases in medical history such as chronic bronchitis, chronic rheumatic diseases, hypertension, cardiomyopathy, diabetes mellitus, renal diseases, eye diseases and tuberculosis (OR = 3.14, 95% CI = 1.56 - 6.33); (5) a greater number (≤ 3) of brothers [OR = 2.08, 95% CI = 1.35 - 3.22); (6) greater numbers (≤ 8) of sexual partners (OR = 2.24, 95% CI = 1.13 - 4.44). Marital status, age at first marriage, educational level, age at first sexual intercourse, frequency of sexual intercourse, venereal diseases, tonsillectomy, appendectomy, hernia inguinale and hydrocele, anthropometric characteristics, smoking history, sport and recreational activities and family history of prostatic neoplasms were not found to be independently related to prostate cancer.

SETTING: Republic of Serbia, excluding Kosovo. OBJECTIVE: To estimate the clinical and epidemiological pattern of tuberculosis (TB) in Serbia during the period 1990-2004. DESIGN: A retrospective analysis of clinical and epidemiological data on TB patients registered in annual TB reports. RESULTS: During the 15-year period, TB incidence levelled off in Serbia. The slightly decreasing trend occurred in both total pulmonary TB (PTB) and laboratory confirmed PTB (PTB+) incidence (P > 0.05), while the trend of extra-pulmonary TB (EPTB) incidence increased slightly (P > 0.05). During the same period, TB mortality showed a significantly decreasing trend (P < 0.05). The mean annual proportion of PTB+ cases among newly reported PTB cases was 62.7%. The mean proportion of EPTB cases among total TB cases was 6.1%. The mean percentage of cases with resistance to at least one anti-tuberculosis drug was 4.8%. CONCLUSION: Thanks to the good organisation and efficient work of anti-tuberculosis dispensaries in Serbia, as well as to the low incidence of AIDS and low frequency of Mycobacterium tuberculosis resistant strains, TB incidence did not increase during the period observed and TB mortality significantly decreased, despite markedly deteriorated socio-economic conditions during the 1990s. © 2007 The Union.

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The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects ≤16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (± one year), sex and place of residence (all were from Belgrade). In the statistical analysis we used X2 test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR=8.58; 95% CI, 3.28-22.46), type 2 diabetes (OR=4.04; 95% CI, 2.31-7.07), allergic diseases (OR=3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR=11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR=3.63; 95% CI, 1.05-12.48).

Purpose: To test some hypotheses concerning risk factors for Hodgkin's disease (HD). Material and methods: A case-control study conducted in Beograd from 1993 to 1996 enrolled 100 patients with histologically confirmed HD and 100 hospitalized non-cancer patients (controls), individually matched by sex, age (±2 years) and place of residence. A number of risk factors was evaluated, in the analysis of which the McNemar's test and univariate and multivariate logistic regression analyses were used. Results: According to multivariate analysis the following factors were significantly related to HD: white collar occupation, daily consumption of milk, cheese and fruit, use of lard for food preparation, age difference between participant and first older sibling >3 years and possession of pets. Conclusion: The results obtained support the hypothesis that, in addition to other factors, some dietary components influence the occurrence of HD.