Browsing by Author "VARAGIć, V.M. (7006591279)"

Summary— Similar to adenosine and some of its derivatives, 5′‐N‐ethylcarboxamideadenosine (NECA) produced a biphasic effect on the isolated hemidiaphragm of the rat: a potentiation of the isometric contraction during direct electrical stimulation (in the presence of dipyridamole), and a depression during indirect electrical stimulation, and particularly so in a partially curarized preparation. The potentiating effect is presumed to be due to activation of the cAMP system, probably through A2 receptor sites, although a differentiation of the receptor subtype could not be made with aminophylline and XAC. Inhibition is most probably due to a depressant action of NECA on the acetylcholine release from the motor nerve terminals. These results accord with our previous findings, suggesting that adenosine may be part of a buffer system which participates in balancing the excitatory and inhibitory influences on skeletal muscle contraction. 1989 Société Française de Pharmacologie et de Thérapeutique

Summary— Similar to adenosine and some of its derivatives, 5′‐N‐ethylcarboxamideadenosine (NECA) produced a biphasic effect on the isolated hemidiaphragm of the rat: a potentiation of the isometric contraction during direct electrical stimulation (in the presence of dipyridamole), and a depression during indirect electrical stimulation, and particularly so in a partially curarized preparation. The potentiating effect is presumed to be due to activation of the cAMP system, probably through A2 receptor sites, although a differentiation of the receptor subtype could not be made with aminophylline and XAC. Inhibition is most probably due to a depressant action of NECA on the acetylcholine release from the motor nerve terminals. These results accord with our previous findings, suggesting that adenosine may be part of a buffer system which participates in balancing the excitatory and inhibitory influences on skeletal muscle contraction. 1989 Société Française de Pharmacologie et de Thérapeutique