Browsing by Author "Tulić, C. (6602213245)"

The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations. © 2016 American Society of Andrology and European Academy of Andrology

The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations. © 2016 American Society of Andrology and European Academy of Andrology

Summary:  A randomized group of 65 men with oligoasthenozoospermia and left side varicocele was subjected to a controlled study with kallikrein. Kallikrein (600 units orally per day) was given to 38 men for a period of 3 months. The other group of 27 men remained untreated but were followed up during the same period of time. After kallikrein treatment significant improvements in sperm quality could be observed: percentage of motile spermatozoa from 24.47 ± 9.01 to 35.26 ± 11.80, percentage of morphologically normal spermatozoa from 58.42 ± 5.86 to 71.05 ± 8.12. There was no improvement in sperm parameters in the untreated group of men. The results suggest that kallikrein therapy is useful for those men who refuse an operative or radiologic treatment of their varicocele and also as a primary or associated therapy of patients who underwent ligature or occlusion of spermatic veins. Zusammenfassung:  An einer Gruppe von 65 Männern mit Oligoasthenozoospermie und linksseitiger Varicocele wurde eine randomisierte kontrollierte Studie mit Kallikrein durchgeführt. 38 Männer erhielten drei Monate lang täglich 600 Einheiten Kallikrein oral. Die übrigen 27 Männer blieben unbehandelt und bildeten die Vergleichsgruppe. Nach drei Monaten hatten sich bei den Männern der Kallikrein‐Gruppe signifikante Verbesserungen der Spermaqualität ergeben: der Anteil motiler Spermatozoen stieg von 24.47 ± 9.01 auf 35.26 ± 11.80%, der Anteil morphologisch normaler Spermatozoen von 58.42 ± 5.86 auf 71.05 ± 8.12%. Bei der unbehandelten Gruppe zeigten sich keine rele‐vanten Änderungen. Aufgrund dieser Ergebnisse erscheint eine Kallikrein‐Anwendung zum einen sinnvoll bei Männern, die eine operative oder radiologische Behandlung ihrer Varicocele verweigern, zum anderen als primäre oder begleitende Therapie bei Patienten nach durchge‐führter Ligatur oder Okklusion der Vena spermatica. 1990 Blackwell Verlag GmbH

Summary:  A randomized group of 65 men with oligoasthenozoospermia and left side varicocele was subjected to a controlled study with kallikrein. Kallikrein (600 units orally per day) was given to 38 men for a period of 3 months. The other group of 27 men remained untreated but were followed up during the same period of time. After kallikrein treatment significant improvements in sperm quality could be observed: percentage of motile spermatozoa from 24.47 ± 9.01 to 35.26 ± 11.80, percentage of morphologically normal spermatozoa from 58.42 ± 5.86 to 71.05 ± 8.12. There was no improvement in sperm parameters in the untreated group of men. The results suggest that kallikrein therapy is useful for those men who refuse an operative or radiologic treatment of their varicocele and also as a primary or associated therapy of patients who underwent ligature or occlusion of spermatic veins. Zusammenfassung:  An einer Gruppe von 65 Männern mit Oligoasthenozoospermie und linksseitiger Varicocele wurde eine randomisierte kontrollierte Studie mit Kallikrein durchgeführt. 38 Männer erhielten drei Monate lang täglich 600 Einheiten Kallikrein oral. Die übrigen 27 Männer blieben unbehandelt und bildeten die Vergleichsgruppe. Nach drei Monaten hatten sich bei den Männern der Kallikrein‐Gruppe signifikante Verbesserungen der Spermaqualität ergeben: der Anteil motiler Spermatozoen stieg von 24.47 ± 9.01 auf 35.26 ± 11.80%, der Anteil morphologisch normaler Spermatozoen von 58.42 ± 5.86 auf 71.05 ± 8.12%. Bei der unbehandelten Gruppe zeigten sich keine rele‐vanten Änderungen. Aufgrund dieser Ergebnisse erscheint eine Kallikrein‐Anwendung zum einen sinnvoll bei Männern, die eine operative oder radiologische Behandlung ihrer Varicocele verweigern, zum anderen als primäre oder begleitende Therapie bei Patienten nach durchge‐führter Ligatur oder Okklusion der Vena spermatica. 1990 Blackwell Verlag GmbH