Browsing by Author "Trajković, G. (9739203200)"

Background: The aim of the study was to examine the frequency and class of life events, as well as social support, in patients with panic disorder (with/without agoraphobia) (PD/PDA) in a 1-year period preceding the onset of panic attacks. Subjects and methods: The study sample included 40 patients (PD/PDA) (of an average age of 39.25, SD 6.96), and 40 matched healthy controls (M 37.50, SD 8.05). The following instruments were applied: DSM-IV criteria for PD/PDA, Stressful Life Events Scale, Social Support Index (SSI), Family Coping Coherence Index (FCCI), Relative and Friend Support (RFS) and Family Hardiness Index (FHI). The study was retrospective. Results: Patients with PD/PDA compared to the healthy controls, had significantly increased ftequency of negative life events (M 3.8, min 0, max 11) (p<0.05). With respect to the class of life events, PD/PDA patients reported significantly more frequently: mild somatic illness, serious somatic illness, conflict with a member of the extended family, separation from a significant person (p<0.05) and frequent marital conflicts (p<0.01). The patients compared to the healthy controls, had significantly lower level of social support by SS1, FH1, and FCCI (p<0.001). By RFS, there were no significant differences between the two groups. Conclusion: Increased frequency of negative life events (particularly somatic illness, interpersonal conflicts and separation), combined with absence of the most part of the supportive quality of the environment (particularly family support), precede the development of PD/PDA in vulnerable persons. © Medicinska naklada - Zagreb.

Background: This study investigated the correlation between cervical cytology, the expression of P16INK4a, and human papilloma virus (HPV) infection. Materials and Methods: The study included 100 subjects with suspected pathological cervical lesions. Cervical smears were analyzed for malignancy and p16INK4p. Histological finding represented "the golden standard". Results: Immunocytochemical analysis of protein p16INK4a expression on epithelial cells of cervical smear demonstrated increased p16INK4a expression in 36.0% of subjects. There was statistically significant positive correlation (Spearman r = 0.70; p < 0.001) between the pathological findings and the intensity of p16INK4a protein expression inside the epithelial cells, as well as with the histological finding (Spearman r = 0.71; p < 0.001). The intensity of p16INK4a protein expression in cytology finding was significantly higher in HPV16 positive patients (MannWhitney test, p = 0.0065). Conclusion: Good correlation between the expression rate and the severity of lesions indicates that this test might improve the results of cytology and HPV screening, as well as the results of predicting the prognosis of the disorder of the cervix.