Browsing by Author "Tomanovic, Marija (58092757700)"

Introduction: This brief picture-oriented case report focuses on typical skin lesions in a patient who developed Ecthyma gangrenosum and pseudomonal sepsis after extensive immunosuppressive therapy for Pemphigus vulgaris. Case presentation: The patient was immunosuppressed with high doses of glucocorticoids and azathioprine; the follow-up after the treatment was not carried out well due to the pandemic conditions and because the patient herself got a Covid infection, which resulted in the development of pseudomonal sepsis and Ecthyma gangrenosum. The outcome was fatal despite extensive broad-spectrum antibiotic therapy, plasmapheresis, and intravenous immunoglobulins. Conclusions: Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired infections, especially in critically ill and immunocompromised patients, because of multi-drug resistance in the first place. Copyright © 2023 Tomanovic et al.

Introduction: This brief picture-oriented case report focuses on typical skin lesions in a patient who developed Ecthyma gangrenosum and pseudomonal sepsis after extensive immunosuppressive therapy for Pemphigus vulgaris. Case presentation: The patient was immunosuppressed with high doses of glucocorticoids and azathioprine; the follow-up after the treatment was not carried out well due to the pandemic conditions and because the patient herself got a Covid infection, which resulted in the development of pseudomonal sepsis and Ecthyma gangrenosum. The outcome was fatal despite extensive broad-spectrum antibiotic therapy, plasmapheresis, and intravenous immunoglobulins. Conclusions: Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired infections, especially in critically ill and immunocompromised patients, because of multi-drug resistance in the first place. Copyright © 2023 Tomanovic et al.

Seborrheic keratosis is the most common slow-growing, benign epithelial tumour, usually appearing on sun-exposed areas. Treatment modalities for seborrheic keratosis may be uncomfortable and/or time-consuming. We present a case series of 12 patients with solitary seborrheic keratosis localized on the face treated with 0.005% calcipotriol ointment. The treatment lasted 3–8 months and resulted in complete regression of the lesions. Remission (follow-up period) lasted from 6 to 10 years. We conclude that topical calcipotriol may be a useful treatment option for seborrheic keratosis. © 2023 The Australasian College of Dermatologists.

Introduction: Tuberculosis (TB) is a chronic, granulomatous, infectious disease caused by the Mycobacterium tuberculosis complex. Cutaneous TB accounts for less than 1–2% of all TB cases. Scrofuloderma is a subcutaneous form of cutaneous TB, which results from direct spreading of infection from deeper tissues. Case reports: We present two patients with scrofuloderma who exhibited typical clinical features but posed significant diagnostic challenges. In the first case, diagnosis was confirmed by polymerase chain reaction (PCR) of a tissue specimen which detected M. tuberculosis. All other microbiological tests, including direct microscopy, acid-fast bacilli smear, mycobacterial cultures, and TB-PCR of caseous discharge, were negative. In the second case, M. tuberculosis was identified via PCR of an ulcer swab, while other tests were negative. Histopathological findings were consistent with cutaneous TB. Both patients were treated with four first-line antitubercular drugs. The first patient developed progressive leukopenia and neutropenia and the treatment was adjusted to exclude ethambutol. Both the patients showed significant clinical improvement shortly after starting therapy. Conclusions: Cutaneous TB is often misdiagnosed due to its rarity and the challenges of microbiological testing, especially in paucibacillary forms. Histopathological features, though suggestive, are not pathognomonic, contributing to diagnostic delays. Increased awareness among dermatologists can lead to earlier diagnosis and better outcomes. Copyright © 2025 Skiljevic et al.

Introduction: Tuberculosis (TB) is a chronic, granulomatous, infectious disease caused by the Mycobacterium tuberculosis complex. Cutaneous TB accounts for less than 1–2% of all TB cases. Scrofuloderma is a subcutaneous form of cutaneous TB, which results from direct spreading of infection from deeper tissues. Case reports: We present two patients with scrofuloderma who exhibited typical clinical features but posed significant diagnostic challenges. In the first case, diagnosis was confirmed by polymerase chain reaction (PCR) of a tissue specimen which detected M. tuberculosis. All other microbiological tests, including direct microscopy, acid-fast bacilli smear, mycobacterial cultures, and TB-PCR of caseous discharge, were negative. In the second case, M. tuberculosis was identified via PCR of an ulcer swab, while other tests were negative. Histopathological findings were consistent with cutaneous TB. Both patients were treated with four first-line antitubercular drugs. The first patient developed progressive leukopenia and neutropenia and the treatment was adjusted to exclude ethambutol. Both the patients showed significant clinical improvement shortly after starting therapy. Conclusions: Cutaneous TB is often misdiagnosed due to its rarity and the challenges of microbiological testing, especially in paucibacillary forms. Histopathological features, though suggestive, are not pathognomonic, contributing to diagnostic delays. Increased awareness among dermatologists can lead to earlier diagnosis and better outcomes. Copyright © 2025 Skiljevic et al.