Browsing by Author "Suvajdzic, N. (7003417452)"

[No abstract available]

Purpose: To test some hypotheses concerning risk factors for Hodgkin's disease (HD). Material and methods: A case-control study conducted in Beograd from 1993 to 1996 enrolled 100 patients with histologically confirmed HD and 100 hospitalized non-cancer patients (controls), individually matched by sex, age (±2 years) and place of residence. A number of risk factors was evaluated, in the analysis of which the McNemar's test and univariate and multivariate logistic regression analyses were used. Results: According to multivariate analysis the following factors were significantly related to HD: white collar occupation, daily consumption of milk, cheese and fruit, use of lard for food preparation, age difference between participant and first older sibling >3 years and possession of pets. Conclusion: The results obtained support the hypothesis that, in addition to other factors, some dietary components influence the occurrence of HD.

Purpose: To test some hypotheses concerning risk factors for Hodgkin's disease (HD). Material and methods: A case-control study conducted in Beograd from 1993 to 1996 enrolled 100 patients with histologically confirmed HD and 100 hospitalized non-cancer patients (controls), individually matched by sex, age (±2 years) and place of residence. A number of risk factors was evaluated, in the analysis of which the McNemar's test and univariate and multivariate logistic regression analyses were used. Results: According to multivariate analysis the following factors were significantly related to HD: white collar occupation, daily consumption of milk, cheese and fruit, use of lard for food preparation, age difference between participant and first older sibling >3 years and possession of pets. Conclusion: The results obtained support the hypothesis that, in addition to other factors, some dietary components influence the occurrence of HD.

It was recently proposed that prolonged hypoxia produces hypomegakaryocytic thrombocytopenia by reducing the pool of committed megakaryocyte progenitor cells at the expense of a greatly expanded erythroid progenitor pool. In order to test this hypothesis we have studied the relationship between megakaryocytopoiesis, erythropoiesis, and granulopoiesis at the level of progenitor cells (megakaryocyte colony-forming units, CFU-Mk; erythroid CFU, CFU-E; erythroid burst-forming units; BFU-E; and granulocyte-macrophage CFU, CFU-GM) in the marrow of rats exposed for 4 weeks to normobaric hypoxia. We have found that hypomegakaryocytic thrombocytopenia was accompanied by decreased CFU-Mk, increased CFU-E, and a normal number of BFU-E and CFU-GM. These results support the hypothesis that prolonged hypoxia reduces the precursor cell commitment to differentiate into the megakaryocyte series by enhancing demand for differentiation into the erythroid cell line. However, the underlying mechanism needs further investigation.

It was recently proposed that prolonged hypoxia produces hypomegakaryocytic thrombocytopenia by reducing the pool of committed megakaryocyte progenitor cells at the expense of a greatly expanded erythroid progenitor pool. In order to test this hypothesis we have studied the relationship between megakaryocytopoiesis, erythropoiesis, and granulopoiesis at the level of progenitor cells (megakaryocyte colony-forming units, CFU-Mk; erythroid CFU, CFU-E; erythroid burst-forming units; BFU-E; and granulocyte-macrophage CFU, CFU-GM) in the marrow of rats exposed for 4 weeks to normobaric hypoxia. We have found that hypomegakaryocytic thrombocytopenia was accompanied by decreased CFU-Mk, increased CFU-E, and a normal number of BFU-E and CFU-GM. These results support the hypothesis that prolonged hypoxia reduces the precursor cell commitment to differentiate into the megakaryocyte series by enhancing demand for differentiation into the erythroid cell line. However, the underlying mechanism needs further investigation.

Treatment options are limited in patients with chronic immune thrombocytopenic purpura (ITP) which has been unresponsive to corticosteroids and/or splenectomy. Mycophenolate mophetil (MMF) is effective in many autoimmune disorders including severe and refractory ITP through its targeting of T-cell and B-cell lymphocytes. We report on the efficacy of MMF (1.5-2g/day) in 16 adults with severe steroid-resistant ITP. MMF was administered for at least 12 weeks (median 37 weeks, range 14-64 weeks). Patients comprised of 10 females and six males, with median pre-treatment platelet counts of 8 × 10 9/L, median age of 55 years, median ITP duration of 58 months and a median of four prior treatments (range 3-8); nine had been previously splenectomized. Eleven patients (69%) responded after 12 weeks of MMF: 6 (55%) achieving complete remission (CR) and five (45%) achieved partial remission (PR). MMF therapeutic responses were better in those patients who had had fewer prior treatments (p < 0.05), and were independent of patient age, sex, disease duration, and splenectomy status (p > 0.05). Five of the 11 responders (45%; 3CR/2PR) had sustained remissions; however, six responders (55%; 3CR/3PR) relapsed after median of 14 weeks (range 9-20). Three of the six relapsing patients responded to MMF reinstitution achieving stabile PRs; three were left untreated as none had further bleeding and their platelets remained at "safe" levels (median 30 × 109/L). The MMF treatment was well tolerated; one heavily pretreated patient developed a bronchopneumonia and a second had an episode of diarrhea. MMF used as a second-line agent can produce a sustained response in severe ITP which has been unresponsive to steroid and/or splenectomy without major toxicity. © 2011 Informa UK Ltd.