Browsing by Author "Stojanović, Miodrag (57210867750)"

Objectives: The aim was to estimate the trend of incidence, mortality and mortality-to-incidence ratio (MIR) in Central Serbia in 1999–2018 and its possible association with the human development index (HDI). Methods: In this study, cancer of unknown primary (CUP) was included as C77-C80 codes. Trend analysis was performed in the Joinpoint Regression Programme version 4.8.0.1. HDI combines life expectancy, educational attainment and gross national income. HDI values for Serbia are extracted from the global bank site. Results: Joinpoint regression analysis of the age-standardised incidence rate of CUP showed a significantly increasing trend with annual percent change (APC) of 8.5% (95% confidence interval [CI] 3.0–14.3%) in males and 7.8% (95%CI 2.7–13.2) in females. The age-standardised mortality rate of CUP showed a significantly decreasing trend with APC of −1.7% (95%CI −2.8 to −0.5%) in males and −1.4% (95%CI −2.7 to −0.1%) in females. MIR showed a significantly decreasing trend with APC of −9.3% (95%CI -14.6 – −3.6%) in males and −7.1% (95%CI −10.5% to −4.2%) in females. The linear regression showed significant inverse association among HDI and the MIR of CUP in males (r2 = 0.464, p = 0.002) and in females (r2 = 0.612, p < 0.001). Conclusions: Decline of MIR was associated with HDI, suggesting that CUP prognosis follows socio-economic status. © 2021 John Wiley & Sons Ltd.

Introduction/Objective Necrotizing soft tissue infection is a life-threatening condition, characterized by widely spread necrosis of the skin, subcutaneous adipose tissue, fascia, and muscle. This study aimed to determine the risk factors associated with lethality due to necrotizing soft tissue infection of perianal and perineal region, for all patients surgically treated at a tertiary referral hospital. Methods A retrospective review of 38 patients with necrotizing soft tissue infection of the perianal and perineal region, in the period between January 2007 and December 2014, was performed. We reviewed sex and age of the patients, the presence of known risk factors (diabetes mellitus, obesity, alcoholism), localization of necrotizing soft tissue infection, duration of symptoms, length of hospitalization, the number of necessary operations done, the performance of the stoma, and the outcome. We used logistic regression to identify the predictors of lethal outcome in a univariate analysis with estimated odds ratios and 95% confidence intervals. Results There was a significantly higher fatality rate in the group of patients over 60 years of age (p < 0.05), with more than 10 days from the onset of symptoms to the treatment (p < 0.05), with a perianal localization (p < 0.05), and stoma creation (p < 0.05). The overall fatality rate was 18.4%. Conclusion Patients’ age, time passed between the onset of the symptoms and the initiation of the treatment, perianal localization, and stoma creation were related to higher lethality risk. © 2017, Serbia Medical Society. All rights reserved.

The aim of the study was to establish better understanding of students' sexual behaviorand their attitudes toward sex. A total of 2.235 students were asked to anonymously complete a 22-item questionnaire referring to their attitudes towards sex and sexual behavior. In this study, 87% of male students and 77% of female students indicated that they expected to have sexual intercourse before marriage, while 22% of male students and 13% of female students approved extramarital sexual intercourse (χ2=38.431, df=1, p<001 and χ2=30.134, df=1, p<0.001, retrospectively). Out of the total number of investigated students, 78% of them reported that they had had sexual experience. A statistically significant difference was found between male (83%) and female (72%) students (χ2=38.404, df=1, p<0.001). It was also found that 58% of both male and female sexually active students had had their first sexual experience with a permanent partner. In addition,41%of sexually active students reported that they had used condom during their first sexual intercourse, while 47% reported having used condom during the last sexual intercourse. The number of students who used condom is small, although it is constantly rising. Since students are more prone to have sexual intercourse with casual partners, much more effort is needed to promote safe sex practice among university students.