Browsing by Author "Stevanovic, Dejan (57461284600)"

Background: Duodenal adenocarcinomas account for 0.3% of all gastrointestinal malignancies. Most of them are found in the second portion of the duodenum, while those in the third and/or fourth portions, particularly at the duodenojejunal flexure, are very rare, representing a separate entity. Case presentation: We had two male patients who presented with non-specific symptoms in the form of pain in the upper abdomen accompanied by nausea and vomiting. After CT diagnostics had revealed duodenal lesions in the region of the Treitz ligament, patients were subjected to operative treatment, with curative intent in the first case and palliative intent in the second case due to peritoneal carcinomatosis. Conclusion: The insidious onset and vague abdominal symptoms, even when the disease has progressed, coupled with the difficulty of viewing this location and performing a biopsy, make diagnosing these neoplasms particularly difficult. The only possible curative option is surgical resection. A higher degree of suspicion and a more aggressive and persistent investigation should lead to earlier treatment, a higher curative resectability rate, and therefore better long-term results. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

Purpose: The purpose of this study was to examine whether microvascular density and the level of proliferation in gastric signet ring cell carcinoma (SRCC) are important factors in the locoregional control of the disease. Methods: Over a period of eight years, gastric resection specimens from 37 patients were examined. The proliferative index (labelled by Ki67) and microvascular density (MVD) index (mvdIDX) (labelled by CD105) were determined for each case of SRCC. Results: Gastric SRCC was diagnosed more often in female than in male patients (21 females, 16 males; p≤0.05) . The average age of female patients was 63 years, while the male patients were 62 years old on average (p=0.702). Immunohistochemical analysis showed that the median numbers of Ki67 positive cells and CD105 positive blood vessels were higher in tumors compared to surrounding non-tumor tissue. Higher proliferative index and higher mvdIDX were also established relative to tumor stage. Correlation analysis showed a high positive correlation between proliferation index and microvascular density (MVD) index (mvdIDX) (correlation coefficient=0.784). Receiver operating characteristics (ROC) analysis showed progression of both indices examined. Conclusion: Our results showed that, although both proliferative and mvdIDXs are reliable, the former had better performance in identifying of disease progression (AUC=0.970). © 2018 Zerbinis Publications. All Rights Reserved.

Purpose: The purpose of this study was to examine whether microvascular density and the level of proliferation in gastric signet ring cell carcinoma (SRCC) are important factors in the locoregional control of the disease. Methods: Over a period of eight years, gastric resection specimens from 37 patients were examined. The proliferative index (labelled by Ki67) and microvascular density (MVD) index (mvdIDX) (labelled by CD105) were determined for each case of SRCC. Results: Gastric SRCC was diagnosed more often in female than in male patients (21 females, 16 males; p≤0.05) . The average age of female patients was 63 years, while the male patients were 62 years old on average (p=0.702). Immunohistochemical analysis showed that the median numbers of Ki67 positive cells and CD105 positive blood vessels were higher in tumors compared to surrounding non-tumor tissue. Higher proliferative index and higher mvdIDX were also established relative to tumor stage. Correlation analysis showed a high positive correlation between proliferation index and microvascular density (MVD) index (mvdIDX) (correlation coefficient=0.784). Receiver operating characteristics (ROC) analysis showed progression of both indices examined. Conclusion: Our results showed that, although both proliferative and mvdIDXs are reliable, the former had better performance in identifying of disease progression (AUC=0.970). © 2018 Zerbinis Publications. All Rights Reserved.

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