Browsing by Author "Starcevic, V. (7005374307)"

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Objective: To compare the concentrations of cytokines belonging to Th17 axis (interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-γ) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity. Design: Cross-sectional study. Subjects: Twenty-six obese women (age 20-52 years, body mass index (BMI): 30-48 kg/m2) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m2). Measurements: Plasma levels of cytokines and leptin, BMI, waist circumference (WC) and insulin resistance index HOMA (homeostatic model assessment). Results: Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-γ, were higher in obese compared with lean women (P=0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r s=0.530), which was at the border of statistical significance (P=0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index. Conclusion: Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels. © 2009 Macmillan Publishers Limited All rights reserved.

Objective: To compare the concentrations of cytokines belonging to Th17 axis (interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-γ) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity. Design: Cross-sectional study. Subjects: Twenty-six obese women (age 20-52 years, body mass index (BMI): 30-48 kg/m2) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m2). Measurements: Plasma levels of cytokines and leptin, BMI, waist circumference (WC) and insulin resistance index HOMA (homeostatic model assessment). Results: Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-γ, were higher in obese compared with lean women (P=0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r s=0.530), which was at the border of statistical significance (P=0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index. Conclusion: Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels. © 2009 Macmillan Publishers Limited All rights reserved.

Juxtaglomerular apparatus was studied morphologically after one hour of total warm kidney ischemia, using specific staining method for juxtaglomerular cell granules and routine H.E. staining. The results show that all the components of JG apparatus recover within 24 hours after ischemic injury. One hour of total warm kidney ischemia does not damage JG apparatus to a great degree.

The experiments done on the isolated right ventricle of rat hear suspended in the bath for isolated organs with oxygenated Tyrode's solution showed that PgI2 (2,3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2,3 x 10-2 mmol - beta adrenoreceptor blocker) or verapamil (4,3 x l0-3 mmol - slow calcium channel blocker).

The experiments done on the isolated right ventricle of rat hear suspended in the bath for isolated organs with oxygenated Tyrode's solution showed that PgI2 (2,3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2,3 x 10-2 mmol - beta adrenoreceptor blocker) or verapamil (4,3 x l0-3 mmol - slow calcium channel blocker).