Browsing by Author "Simeunovic, S. (6603401374)"

Aim. The aim of this study was to evaluate correlation and influence of recreational physical activity during 10 years of follow-up on four types of lipid fractions in school children of the YUSAD study. Methods. School children from Serbia were evaluated on three different occasions when they were 10, 15 and 19/20 years of age, respectively. Four types of lipid fractions, total cholesterol, triglycerides, HDL and LDL, were separately evaluated in physically active boys and girls. Results. We evaluated 1172 children when they were 10 years of age, 870 children when they were 15 and 1230 children when they were 19/20. All children were from the same population. Our results pointed out that there is no linear correlation between the two evaluated variables: physical activity and lipid fractions. However there is a very weak positive or negative correlation of coherence regarding recreational physical activity and the four types of evaluated lipid fractions. Conclusion. Since this period of growth is very specific for metabolic processes that can influence variations of evaluated parameters, such investigation can give us additional knowledge and further directions that could lead to better understanding the correlation of different risk factors on the atherosclerosis development.

Aim. The aim of this study was to evaluate correlation and influence of recreational physical activity during 10 years of follow-up on four types of lipid fractions in school children of the YUSAD study. Methods. School children from Serbia were evaluated on three different occasions when they were 10, 15 and 19/20 years of age, respectively. Four types of lipid fractions, total cholesterol, triglycerides, HDL and LDL, were separately evaluated in physically active boys and girls. Results. We evaluated 1172 children when they were 10 years of age, 870 children when they were 15 and 1230 children when they were 19/20. All children were from the same population. Our results pointed out that there is no linear correlation between the two evaluated variables: physical activity and lipid fractions. However there is a very weak positive or negative correlation of coherence regarding recreational physical activity and the four types of evaluated lipid fractions. Conclusion. Since this period of growth is very specific for metabolic processes that can influence variations of evaluated parameters, such investigation can give us additional knowledge and further directions that could lead to better understanding the correlation of different risk factors on the atherosclerosis development.

Objectives: The use of drugs in an off label or unlicensed manner to treat children is a widespread phenomenon in Europe and the United States. The incidence of unlicensed and off label prescribing in paediatric cardiology practice has not been studied to date. This study was designed to assess the extent and nature of off label and unlicensed drug use in paediatric cardiology inpatients. Methods: In a prospective study, drug prescriptions in a paediatric cardiology ward were reviewed during a 2-year period. Data were collected and analyzed by special software created for this purpose. Results: The children (n=544) studied varied in age from 4 h to 18 years. One or more off label and unlicensed prescriptions were given to 414 (76%) patients. Of the 2,130 prescriptions given during the 2-year period, more than one-half were unlicensed (11%) or off label (47%). While children aged 2-11 years received most of the unlicensed drug prescriptions (17%), neonates, who did not receive unlicensed drugs, led (64%) in the use of off label drugs. Conclusions: This study showed that the problem of off label and unlicensed drug use also exists in paediatric cardiology. The findings imply that the phenomenon of off label and unlicensed use of drugs in children can be correlated with the deficiency of paediatric drug formulations on the global market and insufficient data from clinical studies which must be performed to confirm the efficacy and safety of drugs in the paediatric population. Therefore, efforts to improve paediatric labelling are important and need the full support of all involved. © Springer-Verlag 2005.

Objectives: The use of drugs in an off label or unlicensed manner to treat children is a widespread phenomenon in Europe and the United States. The incidence of unlicensed and off label prescribing in paediatric cardiology practice has not been studied to date. This study was designed to assess the extent and nature of off label and unlicensed drug use in paediatric cardiology inpatients. Methods: In a prospective study, drug prescriptions in a paediatric cardiology ward were reviewed during a 2-year period. Data were collected and analyzed by special software created for this purpose. Results: The children (n=544) studied varied in age from 4 h to 18 years. One or more off label and unlicensed prescriptions were given to 414 (76%) patients. Of the 2,130 prescriptions given during the 2-year period, more than one-half were unlicensed (11%) or off label (47%). While children aged 2-11 years received most of the unlicensed drug prescriptions (17%), neonates, who did not receive unlicensed drugs, led (64%) in the use of off label drugs. Conclusions: This study showed that the problem of off label and unlicensed drug use also exists in paediatric cardiology. The findings imply that the phenomenon of off label and unlicensed use of drugs in children can be correlated with the deficiency of paediatric drug formulations on the global market and insufficient data from clinical studies which must be performed to confirm the efficacy and safety of drugs in the paediatric population. Therefore, efforts to improve paediatric labelling are important and need the full support of all involved. © Springer-Verlag 2005.