Browsing by Author "Reljić, Vesna (55895308600)"

Co-occurrence of blisters in patients with lichen sclerosus (LS) can raise the question of whether they represent a bullous variant of LS or a concomitant autoimmune disorder. We report a rare case of bullous pemphigoid (BP) occurring on previous LS lesions. To the best of our knowledge, this is also the first BP180-negative case reported in literature. Here, we propose alternative mechanisms, independent of BP autoantibodies, that may lead to development of BP on skin affected by LS. In addition, we provide a literature review that explores the underlying pathophysiology and offers practical treatment insights, equipping clinicians with valuable guidance for similar complex cases. © 2024, Association of Slovenian Dermatovenerologists. All rights reserved.

Background and objectives: While most previous surveys on the clinico-epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused on a single disease entity or just one disease group, there have been only few studies examining the incidence of various AIBDs. In the present study, we set out to determine the spectrum of AIBDs, to estimate the incidence of the most common AIBDs, and to examine their temporal trends in Central Serbia over a period of 20 years. Methods: We retrospectively recruited 1,161 new AIBD cases diagnosed in Central Serbia during the period from January 1991 to December 2010. The diagnosis was based on strict clinical, histological, and immunohistological evaluation. Results: The incidence rates were: 4.35 per million population/year (pmp/year) for pemphigus, 4.47 pmp/year for pemphigoid, 1.42 pmp/year for dermatitis herpetiformis (DH), 0.25 pmp/year for linear IgA disease, and 0.08 pmp/year for epidermolysis bullosa acquisita. In the period observed, age-adjusted incidence rates significantly increased for pemphigus and particularly for pemphigoid, whereas they decreased, albeit not significantly, for DH. Conclusions: For the first time, our study evaluates the incidence rates of the entire spectrum of AIBDs in Serbia, and examines their temporal trends over a 20-year period. To the best of our knowledge, our finding of similar incidence rates for pemphigus and pemphigoid has previously not been reported. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Objective − To assess the prevalence of allergic rhinitis and asthma in children with and without parental history of atopic dermatitis (AD) as well as to explore the association between parental history of atopic diseases and presence of allergic rhinitis or asthma in children diagnosed with AD. Methods − From January to June 2014, we recruited a total of 98 children with AD and their parents who presented at the Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia. The parents filled in a questionnaire. The severity of AD was assessed using the SCORing Atopic Dermatitis (SCORAD) Index. Results − Of 98 parents, 33 (33.7%) reported having history of AD. In children with parental history of AD, the prevalence of allergic rhinitis and asthma was 18.2% and 24.2%, respectively. In children without parental history of AD, the prevalence of allergic rhinitis and asthma was 12.3% and 23.1%, respectively. Adjusted logistic regression analyses showed that: neither mothers’ nor fathers’ history AD were associated with presence of allergic rhinitis or asthma; fathers’ history of asthma was associated with presence of asthma and mothers’ history of asthma was associated with presence of allergic rhinitis. Fathers’ history of allergic rhinitis was associated with presence of allergic rhinitis and mothers’ history of allergic rhinitis was associated with presence of asthma. Conclusion − Our findings suggest that, compared to parental history of AD, parental history of asthma and allergic rhinitis were stronger contributors to the presence of atopic comorbid disorders in children with AD. © 2020 by the University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.

Background: Successful control of atopic dermatitis (AD) in children depends on parents' knowledge on the disease and attitude toward ill child, but there is a lack studies exploring parental knowledge, attitude, and behaviors. The aim of this study was to investigate parents' knowledge, attitude, and behavior toward AD. Methods: A cross-sectional study was conducted at the Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, between February 2015 and March 2016. Parents of children with AD were invited to complete the questionnaire, which was comprised of five parts: parental sociodemographic characteristics, demographic and clinical characteristics of children, knowledge, attitude, and behavior. To assess factors associated with a higher knowledge level on AD, stronger positive attitude, and more supportive behavior, we performed two multiple linear regression models. Results: The average parental knowledge score was 9.5 ± 1.9 out of 12. The level of knowledge did not correlate with parental conviction that they were well-informed on AD (ρ = −0.121; P = 0.319). Older (β = 0.08, 95% confidence interval [CI] 0.00–0.16, P = 0.040), married/partnered parents (β = −2.14, 95% CI −3.55 to 0.72, P = 0.004), and those who have had AD themselves were more likely to be more knowledgeable on AD. Older (β = 0.18, 95% CI 0.01–0.34, P = 0.036) and employed (β = 3.99, 95% CI 1.59–6.38, P = 0.002) parents had stronger positive attitudes toward their children with AD. More supportive behavior of parents of children with AD was associated with being older (β = 0.24, 95% CI 0.04–0.45, P = 0.020) and less educated (β = −0.76, 95% CI −1.24 to 0.28, P = 0.003). Conclusion: The importance of understanding AD and accounting for attitudes by family members is obvious for successful control of the disease. © 2017 The International Society of Dermatology