Browsing by Author "Ratkovic, Ana (58541092000)"

• PDL1 expression is a widely used biomarker in selecting patients suitable for immunotherapy. • PDL1 expression over 50% is considered a good predictive biomarker in patients with NSCLC. • New guidelines recommend combination immune and chemotherapy as first line treatment in patients with PDL1 over 1% (including patients with TPS over 50%). • Stratification of patients over 50% of PDL1 expression and response to treatment has not been done. • In our study we showed that very high PDL1 expression (over 80%) is a good predictive biomarker for response to ICI. • Several studies confirmed our results with a relatively small sample size, therefore this could be the guideline for future studies. • Would patients with TPS over 80% benefit more from mono immunotherapy, and patients under that mark from combination immune and chemotherapy? © 2023 Elsevier Inc.

• PDL1 expression is a widely used biomarker in selecting patients suitable for immunotherapy. • PDL1 expression over 50% is considered a good predictive biomarker in patients with NSCLC. • New guidelines recommend combination immune and chemotherapy as first line treatment in patients with PDL1 over 1% (including patients with TPS over 50%). • Stratification of patients over 50% of PDL1 expression and response to treatment has not been done. • In our study we showed that very high PDL1 expression (over 80%) is a good predictive biomarker for response to ICI. • Several studies confirmed our results with a relatively small sample size, therefore this could be the guideline for future studies. • Would patients with TPS over 80% benefit more from mono immunotherapy, and patients under that mark from combination immune and chemotherapy? © 2023 Elsevier Inc.

OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is an irreversible disease and has influence on patients’ quality of life. The aim is to investigate the influence of gender on the illness perception in COPD patients. MATERIALS AND METHODS: This prospective study enrolled 151 COPD patients. For the evaluation of illness perception, we used Brief Illness Perception Questionnaire (BIPQ). RESULTS: Average FEV1 values were significantly different (p = 0.007) in favor of woman compared to men. There was a higher proportion of GOLD stage 3 and less stage 4 in women. We found a significant difference in total BIPQ scores between female and male patients (p = 0.008). Women gave a significantly higher score on question 6 and 8 (p = 0.003). We found a significant difference in total BIPQ scores between female and male patients. Women perceive COPD as a significantly more threatening disease and accept chronic course and long-term treatment. CONCLUSION: COPD is no longer a disease that predominantly affects men. BIPQ is a convenient tool for fast assessment of illness perception for COPD. Patients’ perceptions of COPD is in correlation with gender and GOLD stadium. The results of this study have potential benefits in terms of health promotion and improvement of the quality of life and outcome (Fig. 4, Ref. 21). Text in PDF www.elis.sk © (2023). All rights reserved.

Introduction: The Neutrophil-to-Lymphocyte Ratio (NLR) has been utilized to predict clinical outcomes in cardiovascular diseases, infectious diseases, and solid tumors and it has a potential association with the severity of Chronic Obstructive Pulmonary Disease (COPD). This study aimed to determine whether NLR is a possible predictor of inflammation severity and mortality in COPD. Methodology: A prospective analysis of NLR in 70 COPD patients, and its relation with biochemical, lung function parameters, and mortality was assessed. Results: NLR was negatively associated with oxygen saturation (p < 0.05) and positively related to C-reactive protein (CRP) (p < 0.05), matrix metalloproteinase-9 (MMP-9) (p ≤ 0.001), tissue inhibitor of metalloproteinase-1 (TIMP-1) (p < 0.05), MMP-9/TIMP-1 ratio (p < 0.05), and the modified Medical Research Council dyspnea scale (mMRC) score (p < 0.05). Deceased patients had significantly higher NLR (p < 0.05). Older age and lower levels of saturation were independently associated with higher mortality in COPD patients (p < 0.05). Conclusions: NLR in COPD correlates with inflammation and protease/antiprotease balance, with elevated NLR detected in deceased patients. These findings suggest that NLR can be a helpful clinical marker in COPD. Copyright © 2025 Dimic-Janjic et al.