Browsing by Author "Radovanovic, Z. (7005270902)"

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A case-control study comprised 130 cases affected by chronic lymphocytic leukemia and the same number of individually matched controls, with accidental injuries as a cause of hospitalization. Matching criteria were: sex, age, type of settlement, and area of residence. Both leukemias and all cancers were more frequent among family members of cases, as compared to controls. © 1994 Kluwer Academic Publishers.

The study comprised all 113 clinically and histologically confirmed cases of Hodgkin's disease aged 15-39 years who were treated at the Department of Hematology of the Faculty of Medicine in Belgrade from January, 1 to June, 30,1987. For each patient, two individually matched controls were selected. Neighbourhood controls were the first neighbours of he same sex, age, and residence history. Hospital controls consisted of accindentally injuered individuals, and they were matched in terms of sex, age, place of residence, and educational level. Comparison of cases and controls revealed that removal of the lymphoid tissue (either tonsils or appendix) did not affect the risk of developing Hodgkin's disease in any way. An association found by some previous studies has been explained by the confounding effect of socioeconomic status. © 1991 Gustav Fischer.

An estimated number of HIV infected individuals in Yugoslavia might be about 3000. I.v. drug users are by far the most affected population group. Prevalence of HIV seropositivity among imprisoned drug users in Belgrade approaches 50%. An effective control of unvoluntary homosexual contacts in prisons is not feasible. Having in mind a moral obligation of the society to preserve the health of its confined members, we advocate the right of (voluntary or on request screened) HIV seronegative individuals to chose to share the cell with inmates shown to be HIV seronegative as well.

An estimated number of HIV infected individuals in Yugoslavia might be about 3000. I.v. drug users are by far the most affected population group. Prevalence of HIV seropositivity among imprisoned drug users in Belgrade approaches 50%. An effective control of unvoluntary homosexual contacts in prisons is not feasible. Having in mind a moral obligation of the society to preserve the health of its confined members, we advocate the right of (voluntary or on request screened) HIV seronegative individuals to chose to share the cell with inmates shown to be HIV seronegative as well.

In 64 children with histopathologically confirmed acute appendicitis, the Rh (E) antigen was found to be more frequent than in corresponding, ethnically and geographically matched controls. The Rh phenotype responsible for the increase of E appeared to be CcD-Ee. The difference was highly significant and supported the hypothesis of a polygenic predisposition to acute appendicitis. © 1987 S. Karger AG, Basel.

In 64 children with histopathologically confirmed acute appendicitis, the Rh (E) antigen was found to be more frequent than in corresponding, ethnically and geographically matched controls. The Rh phenotype responsible for the increase of E appeared to be CcD-Ee. The difference was highly significant and supported the hypothesis of a polygenic predisposition to acute appendicitis. © 1987 S. Karger AG, Basel.

Sixty rural patients with upper urothelial tumors (UUT) have been followed for 10-14 years after they underwent surgery. Residential history revealed that 21 of them spent at least 20 years in an area where the Balkan nephropathy (BN) was endemic. These patients experienced a better survival than those who had not been exposed in BN foci. An opposite finding of the only author who previously tried to quantify survival in the same region by a similar approach was explained by two main reasons: his failure to control a considerable age difference between the two groups, and a restriction of his analysis only to the early stages of the tumors.

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During the year 1974, urinary β2-microglobulin (β2mu) was measured at monthly intervals using the first-morning urine sample of randomly selected individuals from the BEN affected village of Petka (416 persons) and from the nearby situated control village of Stubica (216 persons). Initial compliance was complete; over 90% of villagers had at least 10 tests performed. β2mu, as assessed by radial immunodiffusion (RID), was repeatedly (at least twice) positive in 12% and 1.4% of the populations of the endemic and control villages, respectively. Over the 15 years of follow-up (1974 to 1988), none from the control village developed BEN, while many medical records of the cohort exposed to BEN contained data suggestive of BEN. Death from/with BEN was used as a measure of outcome. Incidence density of 12 was 3.3 per 1000 person/years of observation (19/5723). A single positive β2mu test was a sensitive predictor of BEN death (sensitivity = 89.5%). Selecting two or more positive tests as the cut-off point, the specificity and positive predictive value were considerably increased. Using the sulfosalicylic acid test for detection of significant proteinuria, a similar level of validity indices was reached only by four testings.

Baseline data from a study run in 1974, which comprised beta2-microglobulinuria (β2mu) measurements at monthly intervals from 416 members in 112 households from the BEN affected village of Petka, were compared with the results of two subsequent, cross sectional studies. In June 1988, retesting involved 320 available persons from the same households. Another collection of 284 urine specimens took place in October 1989. Prevalence of tubular proteinuria was the same in 1988 and 1989 as it was in 1974, indicating that the level of exposure to nephrotoxic agent did not change over time. Over 94% of the individuals who were always β2mu negative in 1974 remained negative in 1988. By contrast, over two thirds (68.7%) of those who were positive two or more times 14 years ago, tested positive upon re-examination in 1988. Particular interest arises from the data on those initially repeatedly positive persons in whom the overt disease did not occur over time; moreover, some appeared to be unaffected in 1988 and 1989 according to our set of laboratory criteria. The results suggest occasional slow progression and even possible reversibility of tubular lesions in individuals living in the BEN affected environment.