Browsing by Author "Radovanović, Milan (35280696600)"

Intravesical BCG (Bacillus Calmette–Guerin) therapy represents the therapy of choice for intermediary-and high-risk non-muscle invasive bladder cancers after transurethral resection. However, up to 40% of these patients do not show adequate response to the therapy (BCG failure) and 15% of them experience the progression of the disease to muscle-invasive bladder cancer. In such cases, radical cystectomy is indicated. Studies suggest that early radical cystectomy in patients with BCG failure is followed by better survival compared to delayed radical cystectomy. The prediction of response to BCG therapy could en-able early identification of patients on which this therapy would have no effect and who should undergo early radical cystectomy. © 2022, Serbia Medical Society. All rights reserved.

Introduction The trans-isomer of resveratrol is the active ingredient of Poligonum cuspidatum, known for its medicinal properties and traditionally used in the treatment of neuropsychiatric disorders. It is also found abundantly in the skin of red grapes and red wine. Previous studies have suggested that trans-resveratrol demonstrates a variety of pharmacological activities including antioxidant, anti-inflammatory, as well as neuroprotective properties and procognitive effects. Objective The goal of the present study was to examine the influence of trans-resveratrol on behavior in rats and its antidepressant properties. Methods Male Wistar rats were treated intraperitoneally (i.p.) with the increasing doses of trans-resveratrol (5, 10 and 20 mg/kg) or vehicle (dimethyl sulfoxide - DMSO), 30 minutes before testing of the spontaneous locomotor activity or forced swimming. For the experiments, the behavior of the animals was recorded by a digital camera, and the data were analyzed by one-way ANOVA, followed by Tukey post-hoc test. Results Testing of spontaneous locomotor activity, after the application of vehicle or increasing doses of trans-resveratrol, showed no statistically significant difference between groups (p>0.05). In the forced swim test, one-way ANOVA indicated statistically significant effects of trans-resveratrol (p<0.001). Tukey post-hoc test showed that resveratrol significantly decreased immobility time at the doses of 10 mg/kg and 20 mg/kg, manifesting the acute antidepressant-like effects. There were no statistically significant differences between the resveratrol treatment of 5 mg/kg and vehicle (p>0.05). Conclusion The results from our study suggest that transresveratrol produces significant effects in the central nervous system. After single application, it has acute antidepressant effects, but without influence on locomotor activity.

Introduction/Objective Urinary stasis in a transplanted kidney occurs due to ureteral obstruction caused by intrinsic or extrinsic etiological factors. The aim of this study was to determine the prevalence, time of occurrence, and etiopathogenetic factors of urinary stasis and their distribution according to the type of kidney donor. And to analyze the success of different types of surgical and conservative treatment. Methods The retrospective-prospective randomized study included 580 patients transplanted in the Transplant Center, Clinic of Urology, University Clinical Center of Serbia, for a period of 20 years. After diagnosing urinary stasis, minimally invasive or open surgical interventions were performed, while for one group of patients the definitive treatment was non-surgical with observation and active monitoring. The main control parameters during non-surgical treatment were the diameter of pyelon, serum creatinine values, and urine culture findings. Results Urinary stasis was found in 15% of transplanted patients. The largest number of transplanted patients had early urinary stasis, within three months of transplantation (68%). The most common etiological factors of urinary stasis were intrinsic factors (66%), which were significantly more frequent in transplant patients from a living donor. Non-surgical treatment with observation and active monitoring was successfully performed in 22% of the patients. Conclusion The largest number of transplanted patients with urinary stasis has been successfully treated surgically, most often with open surgery. Surgical correction is advised in cases of pronounced dilatation of the canalicular system with a tendency to increase, in progressive decrease in renal function, and recurrent complicated urinary infections refractory to antibiotic therapy. © 2023, Serbia Medical Society. All rights reserved.

Introduction: Vesicovaginal fistulas (WF) are the most common and the most frequent type of urogenital fistulas. They may have a different etiology. In most cases, surgery is required for treatment. Objective: The aim of the study was to analyze the results of surgical therapy of WF in a tertiary level institution over the last decade. Methods: The retrospective study of results was conducted involving a total number of 99 women who were surgically treated for WF at the Clinic of Urology of the Clinical Center of Serbia in Belgrade in the period from 2001-2010. Results: Over the past ten years WF occurred after hysterectomy in 74.7% of cases, and almost twice more frequently after hysterectomy for a benign gynecological disease. In the surgical treatment of primary WF transvesical approach was used in 53.53% (52/99) of cases. Relapses were treated surgically using transperitoneal approach in all cases. No significant difference was found in respect to the applied approach in the surgical treatment of primary fistulas. In even 94% (93/99) of cases the problem of WF was solved by a single surgical intervention only. In total, in 107 interventions 8 (7.4%) relapses were recorded. Conclusion: The study showed that WF occurred after hysterectomy in three quarters of cases, more frequently after hysterectomy due to a benign gynecological disease. Early detection with timely and appropriate treatment of gynecological diseases will reduce the number of conditions that may lead to WF. Surgical treatment of WF yielded satisfactory results; it was shown that even in 94% of cases the problem of WF was solved by a single surgical intervention only, however further improvement is certainly necessary.