Browsing by Author "Popović, V. (35451450900)"

[No abstract available]

[No abstract available]

Therapeutic plasma exchange (TPE) is an alternative treatment for hyperthyroidism, resulting in a rapid decline in plasma thyroid hormones and anti-thyroid antibodies. TPE has also been used both in primary liver disease and in drug-induced cholestasis. Data on thyrotoxic patients with severe hepatic complications are scarce. Cholestasis induced by imidazol-derived anti-thyroid drugs is extremely rare. The use of TPE for treating this complication was not previously reported. We report the experience of one such patient with a favorable response to TPE. A 45-year-old male patient with Graves' disease, presented with severe jaundice and extremely high serum bilirubin levels due to hepatotoxicity induced by tiamazol. Through extensive investigation primary liver disease, including viral, metabolic, neoplastic and autoimmune disease, as a cause of cholestasis were all ruled out. The patient underwent total of 6. TPEs which in combination with low dose of glucocorticoids and standard supportive measures, resulted in normalization of thyroid hormones and normal liver function tests. TPE provided a safe, rapid and effective treatment of severe drug-induced cholestasis and auto immune hyperthyroidism. From this case we conclude that TPE should be considered as a valuable alternative therapeutic option in thyrotoxic patients with severe complications. Guidelines and indication criteria for TPE treatment in patients with hyperthyroidism are still lacking. © 2013 Elsevier Ltd.

In order to test whether prolactin response to challenge with TRH and domperidone, dopamine receptor antagonist, is diagnostic for idiopathic hypothalamic hypogonadism (1HH) we studied 8 normal controls, 9 subjects with delayed sexual development and 6 patients with IHH TRH test (200 μg i.v. holus) and dompericlone (10 mg i.v. bolus) were given on two different days. Prolactin (RIA-Biodata) was determined in blood samples during the test. The basal value of prolactin in subjects with delayed puberty and healthy controls did not differ from basal values of prolactin in patients with IHR. The peak elevation of prolactin after TRH in subjects with delayed puberty and healthy controls did not differ from that in patients with 1HH. After successful treatment of one patient with 1HH (Kallmann's syndrome) with pulsatile s.c. LHRH we did not find any change in the response of prolactin to TRH challenge after 1, 3 and 6 months of treatment, while prolactin response to domperidone increased. Prolactin responses to TRH and domperidone are not differential for the early diagnosis of 1HH. Successful treatment of a patient with 1HH did not change the response of prolactin to TRH, but increased prolactin response to domperidone possibly due to altered steroid milieu. © 1987, J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York. All rights reserved.

In order to test whether prolactin response to challenge with TRH and domperidone, dopamine receptor antagonist, is diagnostic for idiopathic hypothalamic hypogonadism (1HH) we studied 8 normal controls, 9 subjects with delayed sexual development and 6 patients with IHH TRH test (200 μg i.v. holus) and dompericlone (10 mg i.v. bolus) were given on two different days. Prolactin (RIA-Biodata) was determined in blood samples during the test. The basal value of prolactin in subjects with delayed puberty and healthy controls did not differ from basal values of prolactin in patients with IHR. The peak elevation of prolactin after TRH in subjects with delayed puberty and healthy controls did not differ from that in patients with 1HH. After successful treatment of one patient with 1HH (Kallmann's syndrome) with pulsatile s.c. LHRH we did not find any change in the response of prolactin to TRH challenge after 1, 3 and 6 months of treatment, while prolactin response to domperidone increased. Prolactin responses to TRH and domperidone are not differential for the early diagnosis of 1HH. Successful treatment of a patient with 1HH did not change the response of prolactin to TRH, but increased prolactin response to domperidone possibly due to altered steroid milieu. © 1987, J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York. All rights reserved.